Additional file 10 of Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

Additional file 10: Figure S10. The current traces and G-V curves of hERG mutants in the presence or absence of 10 μM APETx1. Current traces of the hERG mutants before and after the administration of 10 μM APETx1 (left). Voltage protocol is illustrated at the bottom of each current trace. Current traces and voltage protocols at arbitrary potentials are depicted with red to clearly indicate the current reduction by the inhibitory effect of APETx1. G-V curves (mean ± SEM) of hERG mutants in the absence (black filled circle and solid line) or presence (red filled circle and solid line) of 10 μM APETx1 (right). The fitting curves of the WT in the absence (black dashed line) and presence (red dashed line) of 10 μM APETx1 are superimposed onto those of the mutants.