Data underlying the manuscript: Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

Summary This dataset underlies the figures and supplementary figures in the manuscript: “Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism”. The related study showed that exchanging the protein source in a high fat, high sugar, westernised diet (WD) from casein to whole-cell lysates of the non-commensal bacterium Methylococcus capsulatus Bath (McB) was sufficient to reverse WD-induced changes in the gut microbiota to a state resembling that of lean, low fat diet-fed mice, both under mild thermal stress (T22°C) and at thermoneutrality (T30°C). Type of data: gut microbiota and cecal SCFA level changes due to change of the protein source in a high fat, high sugar, westernised diet. Subject of data: Mus musculus Population characteristics: 6-7-week-old male C57BL/6JBomTac, C57BL/6JRj, C57BL/6N, C57BL/6N-Rag2Tm1/CipheRj (RAG2-/-) mice acquired from Taconic Laboratories, Denmark, or Janvier Labs, France. Data The raw data underlying the figures and supplementary figures in the related manuscript are shared openly here as .txt files in tab-separated value format. There are 94 files in total, and each is named in accordance with the particular figure and subfigure it underlies. For more details on the particulars of each file, see the figure captions in the related manuscript. Corresponding author(s) for this study Benjamin. A. H. Jensen, Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. Benjamin.jensen@sund.ku.dk. Karsten Kristiansen, Address as above. kk@bio.ku.dk. Tor E. Lea , Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Norway. tor.lea@nmbu.no. Study approval All experiments were conducted in accordance with the EU directive 2010/63/EU as approved by the Danish Animal Experiments Inspectorate (#2014-15-2934-01,027).