Additional file 2 of Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Additional file 2: Fig. S1. Longitudinal MRI of ODS lesion progression and repair. T2-weighted images (top row) from the same rat are presented at five time points: 0 (baseline), 1, 7, 14, and 21 days post-correction (dpc). The depicted slice is located approximately 2 mm rostrally to the crossing of the anterior commissure. From 7 dpc onwards, bilateral lesions appeared in the ventral striatum (arrows). The lesion location was confirmed by LFB/PAS histochemistry. Regions-of-interest (ROIs) were defined within the lesion area as well as in a normal-appearing area of the dorsal striatum. The lesions can also be seen on parameter maps derived from myelin water imaging and diffusion tensor imaging (bottom image). The within-ROI means of the shown parameters are plotted across time.