Additional file 1 of Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma

Additional file 1: Figure S1. Comparison of CIN signatures among prognostic factors of histopathology. a Paired scatter plots of CIN25 (left) and CIN70 (right) expression profiles comparing endometrial carcinomas (red) with paired adjacent normal tissues (blue) from TCGA dataset (n = 23). Each pair of dots indicates the amount of CIN25 or CIN70 expression for a particular patient. P values represent paired t test calculations. b Boxplots of CIN25 (left) and CIN70 (right) expression in normal endometria (blue) and endometrial carcinomas (red). Each dot indicates the amount of CIN25 or CIN70 expression for a particular sample in the GSE63678 dataset. (c) Same as (b) but comparing benign lesions (blue) with endometrial carcinomas (red) from the GSE17025 dataset. P values presented in (b) and (c) are Mann–Whitney test calculations. d Forest plot comparing CIN70 expression in Grade 1 & 2 versus Grade 3 patients. e Forest plot comparing CIN70 expression in EEC versus non-EEC samples. f Forest plot comparing CIN70 expression in Stage I & II versus Stage III & IV patients. In (d), (e) and (f), an inverse variance (IV) fixed effects method was used to meta-analyze the data; squares (blue) represent standardized mean difference (SMD); square size is proportional to weights used in the analysis; bars (gray) represent 95% confidence intervals (CI); diamonds (yellow) represent overall SMD with associated 95% CI (lateral tips). P values: *p