Additional file 6 of Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
Additional file 6: Supplementary Figure 6. To confirm our data on the reduction of 5-Lox staining in cortical neurons after microglia ablation, we performed an additional staining with the mouse anti-5-Lox antibody (monoclonal 5-Lox antibody from BD Biosciences #610694), the same used for human tiss...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Bild |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | J. Michael M. S. Unger R. Poupardin P. Schernthaner H. Mrowetz J. Attems Aigner, L. |
| description | Additional file 6: Supplementary Figure 6. To confirm our data on the reduction of 5-Lox staining in cortical neurons after microglia ablation, we performed an additional staining with the mouse anti-5-Lox antibody (monoclonal 5-Lox antibody from BD Biosciences #610694), the same used for human tissue. With this antibody 5-Lox immunoreactivity was exclusively found in neurons and did not co-localize with Iba1 positive cells in all groups (inserts). However, most interestingly the 5-Lox staining was again reduced in neurons upon microglia ablation. Dapi was used as nucleus stain. Scale: 20 μm (both). |
| doi_str_mv | 10.6084/m9.figshare.12781723 |
| format | Image |
| fullrecord | <record><control><sourceid>datacite_PQ8</sourceid><recordid>TN_cdi_datacite_primary_10_6084_m9_figshare_12781723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_6084_m9_figshare_12781723</sourcerecordid><originalsourceid>FETCH-datacite_primary_10_6084_m9_figshare_127817233</originalsourceid><addsrcrecordid>eNqdjztuwzAQRNmkMJLcwMVewIpkC_6URj5Ik849sRFH5sIkJZAMAqVKlTv4ej6JrSC-QKoZYN4UT6lpVRbLcl0_-E3Ryj5Zjiiq-WpdreaLifrZGiNZusCOWnGgJXUtvUkTu70TJoPeYdzJiJcgySLRAQPBwSPkNOLZghw-Dl2OggDqOdtPHkjC7_Qe-dIu3NZ9WYhHPH0fEz1JAieQlwZ36qZll3D_l7eqfnnePb7ODGduJEP3UTzHQVelHnW03-irjr7qLP55OwMW-GE-</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>image</recordtype></control><display><type>image</type><title>Additional file 6 of Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice</title><source>DataCite</source><creator>J. Michael ; M. S. Unger ; R. Poupardin ; P. Schernthaner ; H. Mrowetz ; J. Attems ; Aigner, L.</creator><creatorcontrib>J. Michael ; M. S. Unger ; R. Poupardin ; P. Schernthaner ; H. Mrowetz ; J. Attems ; Aigner, L.</creatorcontrib><description>Additional file 6: Supplementary Figure 6. To confirm our data on the reduction of 5-Lox staining in cortical neurons after microglia ablation, we performed an additional staining with the mouse anti-5-Lox antibody (monoclonal 5-Lox antibody from BD Biosciences #610694), the same used for human tissue. With this antibody 5-Lox immunoreactivity was exclusively found in neurons and did not co-localize with Iba1 positive cells in all groups (inserts). However, most interestingly the 5-Lox staining was again reduced in neurons upon microglia ablation. Dapi was used as nucleus stain. Scale: 20 μm (both).</description><identifier>DOI: 10.6084/m9.figshare.12781723</identifier><language>eng</language><publisher>figshare</publisher><subject>Biochemistry ; Cancer ; Cell Biology ; FOS: Biological sciences ; FOS: Clinical medicine ; FOS: Health sciences ; Genetics ; Immunology ; Infectious Diseases ; Marine Biology ; Medicine ; Mental Health ; Molecular Biology ; Neuroscience ; Pharmacology</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1653-8046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>776,1888</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.12781723$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>J. Michael</creatorcontrib><creatorcontrib>M. S. Unger</creatorcontrib><creatorcontrib>R. Poupardin</creatorcontrib><creatorcontrib>P. Schernthaner</creatorcontrib><creatorcontrib>H. Mrowetz</creatorcontrib><creatorcontrib>J. Attems</creatorcontrib><creatorcontrib>Aigner, L.</creatorcontrib><title>Additional file 6 of Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice</title><description>Additional file 6: Supplementary Figure 6. To confirm our data on the reduction of 5-Lox staining in cortical neurons after microglia ablation, we performed an additional staining with the mouse anti-5-Lox antibody (monoclonal 5-Lox antibody from BD Biosciences #610694), the same used for human tissue. With this antibody 5-Lox immunoreactivity was exclusively found in neurons and did not co-localize with Iba1 positive cells in all groups (inserts). However, most interestingly the 5-Lox staining was again reduced in neurons upon microglia ablation. Dapi was used as nucleus stain. Scale: 20 μm (both).</description><subject>Biochemistry</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>FOS: Biological sciences</subject><subject>FOS: Clinical medicine</subject><subject>FOS: Health sciences</subject><subject>Genetics</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Marine Biology</subject><subject>Medicine</subject><subject>Mental Health</subject><subject>Molecular Biology</subject><subject>Neuroscience</subject><subject>Pharmacology</subject><fulltext>true</fulltext><rsrctype>image</rsrctype><creationdate>2020</creationdate><recordtype>image</recordtype><sourceid>PQ8</sourceid><recordid>eNqdjztuwzAQRNmkMJLcwMVewIpkC_6URj5Ik849sRFH5sIkJZAMAqVKlTv4ej6JrSC-QKoZYN4UT6lpVRbLcl0_-E3Ryj5Zjiiq-WpdreaLifrZGiNZusCOWnGgJXUtvUkTu70TJoPeYdzJiJcgySLRAQPBwSPkNOLZghw-Dl2OggDqOdtPHkjC7_Qe-dIu3NZ9WYhHPH0fEz1JAieQlwZ36qZll3D_l7eqfnnePb7ODGduJEP3UTzHQVelHnW03-irjr7qLP55OwMW-GE-</recordid><startdate>20200809</startdate><enddate>20200809</enddate><creator>J. Michael</creator><creator>M. S. Unger</creator><creator>R. Poupardin</creator><creator>P. Schernthaner</creator><creator>H. Mrowetz</creator><creator>J. Attems</creator><creator>Aigner, L.</creator><general>figshare</general><scope>DYCCY</scope><scope>PQ8</scope><orcidid>https://orcid.org/0000-0002-1653-8046</orcidid></search><sort><creationdate>20200809</creationdate><title>Additional file 6 of Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice</title><author>J. Michael ; M. S. Unger ; R. Poupardin ; P. Schernthaner ; H. Mrowetz ; J. Attems ; Aigner, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-datacite_primary_10_6084_m9_figshare_127817233</frbrgroupid><rsrctype>images</rsrctype><prefilter>images</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>FOS: Biological sciences</topic><topic>FOS: Clinical medicine</topic><topic>FOS: Health sciences</topic><topic>Genetics</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Marine Biology</topic><topic>Medicine</topic><topic>Mental Health</topic><topic>Molecular Biology</topic><topic>Neuroscience</topic><topic>Pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>J. Michael</creatorcontrib><creatorcontrib>M. S. Unger</creatorcontrib><creatorcontrib>R. Poupardin</creatorcontrib><creatorcontrib>P. Schernthaner</creatorcontrib><creatorcontrib>H. Mrowetz</creatorcontrib><creatorcontrib>J. Attems</creatorcontrib><creatorcontrib>Aigner, L.</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>J. Michael</au><au>M. S. Unger</au><au>R. Poupardin</au><au>P. Schernthaner</au><au>H. Mrowetz</au><au>J. Attems</au><au>Aigner, L.</au><format>book</format><genre>unknown</genre><ristype>GEN</ristype><title>Additional file 6 of Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice</title><date>2020-08-09</date><risdate>2020</risdate><abstract>Additional file 6: Supplementary Figure 6. To confirm our data on the reduction of 5-Lox staining in cortical neurons after microglia ablation, we performed an additional staining with the mouse anti-5-Lox antibody (monoclonal 5-Lox antibody from BD Biosciences #610694), the same used for human tissue. With this antibody 5-Lox immunoreactivity was exclusively found in neurons and did not co-localize with Iba1 positive cells in all groups (inserts). However, most interestingly the 5-Lox staining was again reduced in neurons upon microglia ablation. Dapi was used as nucleus stain. Scale: 20 μm (both).</abstract><pub>figshare</pub><doi>10.6084/m9.figshare.12781723</doi><orcidid>https://orcid.org/0000-0002-1653-8046</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | DOI: 10.6084/m9.figshare.12781723 |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_datacite_primary_10_6084_m9_figshare_12781723 |
| source | DataCite |
| subjects | Biochemistry Cancer Cell Biology FOS: Biological sciences FOS: Clinical medicine FOS: Health sciences Genetics Immunology Infectious Diseases Marine Biology Medicine Mental Health Molecular Biology Neuroscience Pharmacology |
| title | Additional file 6 of Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A27%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-datacite_PQ8&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.au=J.%20Michael&rft.date=2020-08-09&rft_id=info:doi/10.6084/m9.figshare.12781723&rft_dat=%3Cdatacite_PQ8%3E10_6084_m9_figshare_12781723%3C/datacite_PQ8%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |