Additional file 4 of Cytotoxicity study of the interleukin-12-expressing recombinant Newcastle disease virus strain, rAF-IL12, towards CT26 colon cancer cells in vitro and in vivo

Additional file 4: Figure S4. Photomicrograph section of the lung of mice stained with H&E from 4 different groups of mice a Normal, b Untreated, c AF2240-i-treated, and d rAF-IL12-treated. Normal group showed normal alveolar morphology; alveolar air space (green arrow) and alveolar capillary (yellow arrow). Untreated and rAF-IL12-treated showed normal alveolar morphology; alveolar air space (green arrow) and alveolar capillary (yellow arrow) but with mild thickening of the alveolar interstitial wall due to leucocytic infiltration (blue arrow). AF2240-i-treated showed pronounced thickening of the alveolar interstitial wall due to leucocytic infiltration (blue arrow). AV alveolar duct, V vein, BR bronchiole, AV alveoli. Magnification: 100X; H&E scale bar = 200 µm.