Underlying data for figures – Part 1: standard diet

Data supporting “The KCNJ11-E23K gene variant reduces glucose tolerance and accelerates diet-induced diabetes progression in mice by impairing glucose-induced insulin secretion”.Underlying data for figures – Part 1: standard diet.Figure 1B – Data on the electrophysiological effect of the Kcnj11-K23 allele in isolated beta cells.Figure 2A – Data on the body weight of female and male mice carrying two risk alleles (KK) or none (EE), from 3 to 18 weeks of age.Figure 2B – Data on the fed blood glucose concentration of female and male mice carrying two risk alleles (KK) or none (EE), from 7 to 17 weeks of age.Figures 3A,3C & 3D and supplemental figures 2 & 3 – File 1: Glucose data on the IPGTT of female and male mice carrying two risk alleles (KK) or none (EE), at 12 weeks of age. File 2: Data on the plasma insulin concentrations measured during the IPGTT. Mouse numbering is consistent between file 1 and 2.Figure 3B - Glucose data on the IPITT of female and male mice carrying two risk alleles (KK) or none (EE), at 16 weeks of age.Figure 4A – Data on glucose stimulated insulin secretion from pancreatic islets isolated from female and male mice, carrying two risk alleles (KK) or none (EE), at 18 weeks of age.Figure 4B – Data on islet insulin content from pancreatic islets isolated from female and male mice, carrying two risk alleles (KK) or none (EE), at 18 weeks of age.