Additional file 3 of All-trans retinoic acid reduces cancer stem cell-like cell-mediated resistance to gefitinib in NSCLC adenocarcinoma cells

Additional file 3 : Figure S3. A potential mechanism by which ATRA regulates the response of lung cancer stem cells to gefitinib. ATRA binds and activates RARβ complex and related signaling molecules. The interaction of C/EBP homologous protein (GADD153) with GADD153-CCAAT-enhancing binding protein-...

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Hauptverfasser:	Yao, Wenxiu, Wang, Liyang, Huang, Huan, Li, Xin, Wang, Pinjia, Mi, Kun, Cheng, Jia, Liu, Huifen, Gu, Cuirong, Huang, Lingxiao, Huang, Jianming
Format:	Bild
Sprache:	eng
Schlagworte:	Biochemistry Biophysics Biotechnology Cancer Cell Biology Chemical Sciences not elsewhere classified Developmental Biology FOS: Biological sciences FOS: Health sciences Genetics Hematology Infectious Diseases Medicine Molecular Biology Pharmacology Space Science Virology
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Zusammenfassung:	Additional file 3 : Figure S3. A potential mechanism by which ATRA regulates the response of lung cancer stem cells to gefitinib. ATRA binds and activates RARβ complex and related signaling molecules. The interaction of C/EBP homologous protein (GADD153) with GADD153-CCAAT-enhancing binding protein-β (C/EBP-β) results in a decreased cellular availability of C/EBP-β for binding to the Raldh1 CCAAT box, and high ATRA levels can sequester interaction of C/EBP-β with GADD153 to suppress expression of Raldh1 gene.
DOI:	10.6084/m9.figshare.12135366