Additional file 3 of A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability

Additional file 3 of A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability

Additional file 3: (A) Significant cell loss in the CA1 but not CA3 region of the hippocampus in 36-week-old adult GluA2+/ECS(G) mice as compared to WT littermates (n = 3/genotype; unpaired t-test). (B) IBA1+ cell quantification in the CA1 and CA3 of 36-week-old GluA2+/ECS(G) mice as compared to WT...

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Bibliographische Detailangaben
Hauptverfasser: Konen, Lyndsey, Wright, Amanda, Royle, Gordon, Morris, Gary, Lau, Benjamin, Seow, Patrick, Zinn, Raphael, Milham, Luke, Vaughan, Christopher, Vissel, Bryce
Format: Bild
Sprache:eng
Schlagworte:
Cell Biology
Developmental Biology
FOS: Biological sciences
FOS: Health sciences
Genetics
Hematology
Mental Health
Neuroscience
Pharmacology
Physiology
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Zusammenfassung:Additional file 3: (A) Significant cell loss in the CA1 but not CA3 region of the hippocampus in 36-week-old adult GluA2+/ECS(G) mice as compared to WT littermates (n = 3/genotype; unpaired t-test). (B) IBA1+ cell quantification in the CA1 and CA3 of 36-week-old GluA2+/ECS(G) mice as compared to WT littermates (n = 3/genotype).
DOI:10.6084/m9.figshare.11906742