MOESM12 of Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C
Additional file 12: Figure S12. Activation of APC-associated co-stimulatory molecules is implicated in Npc1-/-/App-/- mouse cerebella. In Npc1-/-/App-/- mouse cerebella, 32 genes related to CD40, 12 genes related to ICAM1, and 6 genes related to CD86 were differentially expressed when compared with...
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| creator | Shin, Samuel Shin, Alexandra Mayagoitia, Karina Siebold, Lorraine Rubini, Marsilio Wilson, Christopher Bellinger, Denise Soriano, Salvador |
| description | Additional file 12: Figure S12. Activation of APC-associated co-stimulatory molecules is implicated in Npc1-/-/App-/- mouse cerebella. In Npc1-/-/App-/- mouse cerebella, 32 genes related to CD40, 12 genes related to ICAM1, and 6 genes related to CD86 were differentially expressed when compared with wildtype littermates (Npc1+/+/App+/+). All differentially expressed genes (DEGs) are localized to their sub-cellular location. All plotted DEGs meet the significance cutoff of fold-change (absolute FC > 1.5) and p-value (p < 0.05). *Duplicate identifiers used for the same gene. A detailed key for IPA molecular shape, color, and interaction is provided in Fig. 4. |
| doi_str_mv | 10.6084/m9.figshare.11393469 |
| format | Image |
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Activation of APC-associated co-stimulatory molecules is implicated in Npc1-/-/App-/- mouse cerebella. In Npc1-/-/App-/- mouse cerebella, 32 genes related to CD40, 12 genes related to ICAM1, and 6 genes related to CD86 were differentially expressed when compared with wildtype littermates (Npc1+/+/App+/+). All differentially expressed genes (DEGs) are localized to their sub-cellular location. All plotted DEGs meet the significance cutoff of fold-change (absolute FC > 1.5) and p-value (p < 0.05). *Duplicate identifiers used for the same gene. A detailed key for IPA molecular shape, color, and interaction is provided in Fig. 4.</description><identifier>DOI: 10.6084/m9.figshare.11393469</identifier><language>eng</language><publisher>figshare</publisher><subject>Biochemistry ; Cell Biology ; Developmental Biology ; FOS: Biological sciences ; FOS: Clinical medicine ; Genetics ; Immunology ; Molecular Biology ; Neuroscience ; Physiology</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1894</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.6084/m9.figshare.11393469$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Shin, Samuel</creatorcontrib><creatorcontrib>Shin, Alexandra</creatorcontrib><creatorcontrib>Mayagoitia, Karina</creatorcontrib><creatorcontrib>Siebold, Lorraine</creatorcontrib><creatorcontrib>Rubini, Marsilio</creatorcontrib><creatorcontrib>Wilson, Christopher</creatorcontrib><creatorcontrib>Bellinger, Denise</creatorcontrib><creatorcontrib>Soriano, Salvador</creatorcontrib><title>MOESM12 of Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C</title><description>Additional file 12: Figure S12. Activation of APC-associated co-stimulatory molecules is implicated in Npc1-/-/App-/- mouse cerebella. In Npc1-/-/App-/- mouse cerebella, 32 genes related to CD40, 12 genes related to ICAM1, and 6 genes related to CD86 were differentially expressed when compared with wildtype littermates (Npc1+/+/App+/+). All differentially expressed genes (DEGs) are localized to their sub-cellular location. All plotted DEGs meet the significance cutoff of fold-change (absolute FC > 1.5) and p-value (p < 0.05). *Duplicate identifiers used for the same gene. 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Activation of APC-associated co-stimulatory molecules is implicated in Npc1-/-/App-/- mouse cerebella. In Npc1-/-/App-/- mouse cerebella, 32 genes related to CD40, 12 genes related to ICAM1, and 6 genes related to CD86 were differentially expressed when compared with wildtype littermates (Npc1+/+/App+/+). All differentially expressed genes (DEGs) are localized to their sub-cellular location. All plotted DEGs meet the significance cutoff of fold-change (absolute FC > 1.5) and p-value (p < 0.05). *Duplicate identifiers used for the same gene. A detailed key for IPA molecular shape, color, and interaction is provided in Fig. 4.</abstract><pub>figshare</pub><doi>10.6084/m9.figshare.11393469</doi><oa>free_for_read</oa></addata></record> |
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| title | MOESM12 of Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C |
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