MOESM12 of Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

Additional file 12: Figure S12. Activation of APC-associated co-stimulatory molecules is implicated in Npc1-/-/App-/- mouse cerebella. In Npc1-/-/App-/- mouse cerebella, 32 genes related to CD40, 12 genes related to ICAM1, and 6 genes related to CD86 were differentially expressed when compared with wildtype littermates (Npc1+/+/App+/+). All differentially expressed genes (DEGs) are localized to their sub-cellular location. All plotted DEGs meet the significance cutoff of fold-change (absolute FC > 1.5) and p-value (p < 0.05). *Duplicate identifiers used for the same gene. A detailed key for IPA molecular shape, color, and interaction is provided in Fig. 4.