Fig. 5 in Karanjin

Fig. 5 in Karanjin

Fig. 5. Proposed karanjin mediated mechanism: I. Karanjin suppress TNFα production; II. Karanjin inhibits protein tyrosine phosphatase-1β (PTP-1β) which suppresses IRS-1 and activates AMPK and induces GLUT4 translocation; III. Karanjin inhibits degradation of I- κB; IV. Karanjin inhibits NF- κB tran...

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Hauptverfasser: Singh, A., Bhatt, G., Gujre, N., Mitra, S., Swaminathan, R., Limaye, A.M., Rangan, L.
Format: Bild
Sprache:eng
Schlagworte:
Biodiversity
Taxonomy
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Zusammenfassung:Fig. 5. Proposed karanjin mediated mechanism: I. Karanjin suppress TNFα production; II. Karanjin inhibits protein tyrosine phosphatase-1β (PTP-1β) which suppresses IRS-1 and activates AMPK and induces GLUT4 translocation; III. Karanjin inhibits degradation of I- κB; IV. Karanjin inhibits NF- κB translocation to nucleus; V. Karanjin suppresses ROS; VI. Induces cell cycle arrest, G2/M arrest and increase in subG1 population; VII. Karanjin induce BAX/BCL-2 ratio by inhibiting BCL-2 expression; VIII. Karanjin induce p53 expression; IX. Karanjin induces drug efflux and metabolism.
DOI:10.5281/zenodo.8291572