Topological characterization of the retinal microvascular network visualized by portable fundus camera- effects of chronic disease (TREND2) database

Introduction Topological characterization of the Retinal microvascular nEtwork visualized by portable fuNDus camera (TREND 2) is a database of digital color eye fundus images created as an addition to TREND database (https://zenodo.org/badge/DOI/10.5281/zenodo.4521044.svg). TREND 2 databse was created by medical professionals of the Faculty of Medicine of the University of Montenegro in 2023. Purpose 1) to provide a standard that defines normal and abnormal retinal anatomy and microvascular geometry as it appears when visualized by the portable fundus camera 2) to help the development of new methods for stratification of the risk for the development of various eye diseases, as well as systemic diseases that affect microvasculature 3) to aid the development of biomarkers of accelerated aging 4) to provide a standard that can be used to develop software for segmentation of retinal microvasculature, grading the quality of retinal digital images, and computer-aided diagnosis of systemic and chronic diseases. All color digital images were acquired with a hand-held portable, non-mydriatic MiiS HORUS Scope DEC 200 with 45º FOV and 2560 X 1920 pixel resolution. Data The TREND public database contains 28 color fundus images of old subjects (20 images from subjects with one or more chronic diseases such as type 2 diabetes mellitus, hypertension or Alzheimer's dementia- O_CD group, and 8 images from subjects with no chronic diseases- O_NCD group). Each image is associated with a corresponding binarized image of the manually segmented microvascular network. Inclusion and Exclusion Criteria O_NCD group O_CD group Inclusion Criteria Inclusion Criteria - at least 56 years old - at least 56 years old - no current acute disease - no history of alcohol, or drug abuse, or psychiatric disease - no current acute disease - no history of alcohol, or drug abuse, or psychiatric disease - no history of alcohol, or drug abuse, or psychiatric disease - no history of alcohol, or drug abuse, or psychiatric disease - negative history of any chronic disease - controlled hypertension (blood pressure