Integrative structure determination of PTBP1-viral IRES complex in solution

Ensemble structure model of the RNA-binding protein PTBP1 in complex with the internal ribosome entry site (IRES) of encephalomyocarditis virus (EMCV) RNA and data underlying these models. Main ensemble based on all restraints (corresponding to Figure 2 in the associated paper) Ensemble obtained with only DEER distance distribution restraints corresponding to Figure S7(A) in the Supplementary Material of the associated paper Validation ensemble obtained with all restraints after removing the conformers of the main ensemble from the raw ensemble corresponding to Figure S7(B) inthe Supplementary Material of the associated paper Ensemble obtianed with all restraints by fitting populations with a non-negative linear least squares (NNLLSQ) approach corresponding to Figure S8(A) in ths Supplementary Material of the associated paper Primary DEER-EPR data underlying site-to-site distance distributions for 35 spin-label pairs and corresponding distanace distributions Small-angle neutron scattering (SANS) curves a two detector distances with corresponding resolution files and a small-angle x-ray scattering (SAXS) curve Restraint file for the ensemble fit with MMMx software, specifying the mean distances and standrad deviations of distance distributions that were also used for specifying lower and upper distance bounds in CYANA generation of the raw ensemble Source data for the figures in the associated paper Source data for the tables in the associated paper All ensembles are ZIP files containing single PDB files for all conformers and an ensemble specification that reports populations for all conformers.