FORMULATION AND ESTIMATION OF ATOMOXETINE HCL BUCCAL DRUG DELIVERY SYSTEM

The study focused on developing and evaluating mucoadhesive buccal films for enhanced drug delivery using a solvent casting method. Among the formulations (F1-F9), F2 emerged as the optimized batch, demonstrating superior quality attributes. F2 exhibited excellent transparency, minimal weight variation (43.56%), low moisture content (3.2%), optimal thickness (0.02 mm), high folding endurance (110), and a pH of 6.8. It also achieved the highest drug content (98.14%) and tensile strength (25.63 gm/mm²), ensuring stability, robustness, and effective drug delivery. The ex-vivo diffusion study confirmed that F2 achieved 95.56% drug permeation at 10 minutes, surpassing other formulations. Stability studies over three months revealed no significant changes in thickness, drug content, or drug release. The results demonstrate that formulation F2 is a promising candidate for mucoadhesive buccal drug delivery, offering consistent quality, efficient drug release, and stability over time. Keywords: Mucoadhesive buccal films, drug delivery, solvent casting, folding endurance, drug content, ex-vivo diffusion, stability studies.