A REVIEW ON: ADAPALENE IN COMBINATION WITH TEA TREE HERBAL OIL FOR ACNE TREATMENT

Acne is the most common skin disease worldwide. Acne is estimated to affect 9.4% of the world's population, making it the eighth most common disease worldwide. Acne vulgaris is caused by disruption and inflammation of the pilosebaceous unit (hair follicles and sebaceous glands) leading to the formation of comedones, papules, pustules, nodules, and/or cysts. Acne appears on the face and upper body. It mostly affects young people. Adapalene binds to retinoic acid receptors (RAR)-beta and RAR-gamma; Retinoid activation is known to affect cell growth and differentiation, and adapalene has been shown to inhibit HeLa cell proliferation and human keratinocyte differentiation. These effects explain the anti-comedogenic and anti-comedogenic properties of adapalene. It acts as an anti-inflammatory agent, inhibits respiration and increases membrane permeability of microbial cells. Adapalene and herbal oil together create a synergistic effect. Adapalene and herbal oil will cause redness or swelling when taken alone, although not together, so the combination of adapalene and herbal oil will be effective in treating acne. Among herbal oils, some oils are used especially in the treatment of acne. Oils such as tea tree oil, neem oil and lemongrass oil have antibacterial properties and can help treat acne.tea tree oil has better effect along with adapalene for acne treatment. Niosomal gel preparation of adapalene in combination with tree oil will have potential effectivity against acne. Key words: Acne, Acne Vulgaris, Pilosebaceous gland, Comedones, Papules, Adapalne, Herbal oil, tea tree oil, niosomal gel.