FORMULATION AND EVALUATION OF LINAGLIPTIN MICROSPHERES BY USING DIFFERENT POLYMERS

In the present work, Microspheres of Linagliptin using PLGA, Ethyl cellulose and HPMC K4M as polymers were formulated to deliver Linagliptin via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Linagliptin microspheres. In this work an effort was made to formulate microsphere of Linagliptin by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the evaluation parameters was considered as best formulation of Linagliptin. The present study conclusively that Linagliptin microsphere could be prepared successfully and formulation F5 was shows satisfactory result. Keywords: Linagliptin, PLGA, Ethyl cellulose and HPMC K4M and Microspheres.