Data from: Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma

Background. This present study aimed to assess if clinical, laboratory and MRI were an accurate benchmark in assessing the effectiveness of neoadjuvant chemotherapy in osteosarcoma patients. Methods. This was an observational analytic study with a cross-sectional design. Research subjects were selected using the total sampling method from osteosarcoma patients who underwent neoadjuvant chemotherapy during the period between January 2017– July 2019. Results.Of the 58 patients included in this study, 38 were male and 20 were female aged 5 - 67 years (mean,16-year-old. 37(63.8%) patients underwent neoadjuvant chemotherapy with CAI regimens and 13 (36.2%) with CA. The tumors were classified as stage IIB in 43 (74.1%) patients and stage III in15 (25.9%) patients. After undergoing neoadjuvant chemotherapy, 4 patients had poor MSTS, 30 patients had fair MSTS, 17 and 7 patients had good and excellent MSTS score, respectively. Spearman’s test revealed no correlation between tumor necrosis after neoadjuvant chemotherapy with a reduction in tumor size and MSTS score. Wilcoxon test showed significant differences between ALP, ESR, and NLR before and after neoadjuvant chemotherapy in the poor-response group. We found no significant difference between LDH and LMR before and after neoadjuvant chemotherapy in the good-response group. We had 9 patients for ADC value only. No significant statistical differences were found in tumor volumes after chemotherapy in both groups. Conclusion. We demonstrated that ALP level after neoadjuvant chemotherapy was markedly decreased, and was statistically significant in the poor-response group. We also demonstrated that LDH value before neoadjuvant chemotherapy had a strong correlation with degree of necrosis and could be used as a predictive indicator. NLR and LMR cannot be independent prognostic factors. MRI plays an important role in evaluating tumor volumes and preoperative radiological changes, using DWI and water diffusion to predict histological necrosis.