Data from: The consequences of not accounting for background selection in demographic inference
Recently, there has been increased awareness of the role of background selection (BGS) in both data analysis and modelling advances. However, BGS is still difficult to take into account because of tractability issues with simulations and difficulty with nonequilibrium demographic models. Often, simp...
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Zusammenfassung: | Recently, there has been increased awareness of the role of background
selection (BGS) in both data analysis and modelling advances. However, BGS
is still difficult to take into account because of tractability issues
with simulations and difficulty with nonequilibrium demographic models.
Often, simple rescaling adjustments of effective population size are used.
However, there has been neither a proper characterization of how BGS could
bias or shift inference when not properly taken into account, nor a
thorough analysis of whether rescaling is a sufficient solution. Here, we
carry out extensive simulations with BGS to determine biases and behaviour
of demographic inference using an approximate Bayesian approach. We find
that results can be positively misleading with significant bias, and
describe the parameter space in which BGS models replicate observed
neutral nonequilibrium expectations. |
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DOI: | 10.5061/dryad.37hc1 |