Figure 8: Effects of the NPR-C Agonist cANF on Ang II-Mediated Alterations in SAN Fibrosis

Figure 8: Effects of the NPR-C Agonist cANF on Ang II-Mediated Alterations in SAN Fibrosis

(A) SAN immunohistochemistry for HCN4 (top) and picrosirius red staining of fibrosis (bottom) for wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). Bars = 50 μM. (B) Summary of the effects of cANF on Ang II-mediated fibrosis in the SAN. *p < 0.001 versus sa...

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Hauptverfasser: Mackasey, Martin, Egom, Emmanuel E., Jansen, Hailey J., Hua, Rui, Moghtadaei, Motahareh, Liu, Yingjie, Kaur, Jaspreet, McRae, Megan D., Bogachev, Oleg, Rafferty, Sara A., Ray, Gibanananda, Kirkby, Adam W., A. Rose, Robert
Format: Bild
Sprache:eng
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Cardiology (incl. cardiovascular diseases)
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Zusammenfassung:(A) SAN immunohistochemistry for HCN4 (top) and picrosirius red staining of fibrosis (bottom) for wild-type mice treated with saline, Ang II, or Ang II plus cANF (0.07 or 0.14 mg/kg/day). Bars = 50 μM. (B) Summary of the effects of cANF on Ang II-mediated fibrosis in the SAN. *p < 0.001 versus saline; #p = 0.037 versus saline; +p < 0.001 versus Ang II; ∧p = 0.004 versus Ang II plus cANF (0.07) by 1-way analysis of variance with Tukey post hoc test; n = 5 hearts for each group.
DOI:10.25407/jacbts.8253269