Supplementary Figure 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing
Abstract Background: This study aimed to investigate the expression of regeneration-related genes in canine urine during bladder repair. Materials & methods: Canine urine samples were collected after partial cystectomy. Regenerative mRNA of hypoxia-inducible factor (HIF), vascular endothelial gr...
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| creator | Yi, Xianlin Liu, Chanzhen Zhou, Juan Li, You Lu, Haoyuan Lu, Yulei Wei, Wei Wu, Mingsong |
| description | Abstract
Background: This study aimed to investigate the expression of regeneration-related
genes in canine urine during bladder repair. Materials & methods:
Canine urine samples were collected after partial cystectomy. Regenerative mRNA
of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF),
key stem cell transcription factors, and cholinergic signals were detected. Results:
HIF-1α, VEGF, CD44, interleukin-6, and prominin 1 expression in canine urine
after partial cystectomy exhibited two similar peaks at ~2 weeks. HIF-1α and
VEGF expression was higher in the afternoon than in the morning. The expression
of key stem cell transcription factors and cholinergic signals also exhibited a
rhythm along with bladder healing. Conclusions: The expression of
HIF-1α, VEGF, key stem cell transcription factors, and cholinergic signals
exhibited a time curve distribution during canine bladder healing. The
expression trend of some regenerative genes was similar during bladder healing,
and a cooperative effect may exist. |
| doi_str_mv | 10.25402/rme.15090141 |
| format | Image |
| fullrecord | <record><control><sourceid>datacite_PQ8</sourceid><recordid>TN_cdi_datacite_primary_10_25402_rme_15090141</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_25402_rme_15090141</sourcerecordid><originalsourceid>FETCH-datacite_primary_10_25402_rme_150901413</originalsourceid><addsrcrecordid>eNqVjr0OgjAURrs4GHV0vy8AtgiDbsZInBz8mZuLvWBjKeQCGt5eNPoATt9yvpMjxFzJMEpiGS24pFAlciVVrMYCT11dOyrJt8g9pLbomECt4cLWU5BhQwaYCvLE2NoHwfGwgcxWJfKduIG8YugG9v3OHBpDDM-q8wZuhM76YipGObqGZt-diCDdnbf7wGCLV9uSrtkOtl4rqT-JekjUv8Tlv_wLZlRKMw</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>image</recordtype></control><display><type>image</type><title>Supplementary Figure 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing</title><source>DataCite</source><creator>Yi, Xianlin ; Liu, Chanzhen ; Zhou, Juan ; Li, You ; Lu, Haoyuan ; Lu, Yulei ; Wei, Wei ; Wu, Mingsong</creator><creatorcontrib>Yi, Xianlin ; Liu, Chanzhen ; Zhou, Juan ; Li, You ; Lu, Haoyuan ; Lu, Yulei ; Wei, Wei ; Wu, Mingsong</creatorcontrib><description>Abstract
Background: This study aimed to investigate the expression of regeneration-related
genes in canine urine during bladder repair. Materials & methods:
Canine urine samples were collected after partial cystectomy. Regenerative mRNA
of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF),
key stem cell transcription factors, and cholinergic signals were detected. Results:
HIF-1α, VEGF, CD44, interleukin-6, and prominin 1 expression in canine urine
after partial cystectomy exhibited two similar peaks at ~2 weeks. HIF-1α and
VEGF expression was higher in the afternoon than in the morning. The expression
of key stem cell transcription factors and cholinergic signals also exhibited a
rhythm along with bladder healing. Conclusions: The expression of
HIF-1α, VEGF, key stem cell transcription factors, and cholinergic signals
exhibited a time curve distribution during canine bladder healing. The
expression trend of some regenerative genes was similar during bladder healing,
and a cooperative effect may exist.</description><identifier>DOI: 10.25402/rme.15090141</identifier><language>eng</language><publisher>Taylor & Francis</publisher><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>780,1892</link.rule.ids><linktorsrc>$$Uhttps://commons.datacite.org/doi.org/10.25402/rme.15090141$$EView_record_in_DataCite.org$$FView_record_in_$$GDataCite.org$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Yi, Xianlin</creatorcontrib><creatorcontrib>Liu, Chanzhen</creatorcontrib><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Lu, Haoyuan</creatorcontrib><creatorcontrib>Lu, Yulei</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Wu, Mingsong</creatorcontrib><title>Supplementary Figure 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing</title><description>Abstract
Background: This study aimed to investigate the expression of regeneration-related
genes in canine urine during bladder repair. Materials & methods:
Canine urine samples were collected after partial cystectomy. Regenerative mRNA
of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF),
key stem cell transcription factors, and cholinergic signals were detected. Results:
HIF-1α, VEGF, CD44, interleukin-6, and prominin 1 expression in canine urine
after partial cystectomy exhibited two similar peaks at ~2 weeks. HIF-1α and
VEGF expression was higher in the afternoon than in the morning. The expression
of key stem cell transcription factors and cholinergic signals also exhibited a
rhythm along with bladder healing. Conclusions: The expression of
HIF-1α, VEGF, key stem cell transcription factors, and cholinergic signals
exhibited a time curve distribution during canine bladder healing. The
expression trend of some regenerative genes was similar during bladder healing,
and a cooperative effect may exist.</description><fulltext>true</fulltext><rsrctype>image</rsrctype><creationdate>2021</creationdate><recordtype>image</recordtype><sourceid>PQ8</sourceid><recordid>eNqVjr0OgjAURrs4GHV0vy8AtgiDbsZInBz8mZuLvWBjKeQCGt5eNPoATt9yvpMjxFzJMEpiGS24pFAlciVVrMYCT11dOyrJt8g9pLbomECt4cLWU5BhQwaYCvLE2NoHwfGwgcxWJfKduIG8YugG9v3OHBpDDM-q8wZuhM76YipGObqGZt-diCDdnbf7wGCLV9uSrtkOtl4rqT-JekjUv8Tlv_wLZlRKMw</recordid><startdate>20210802</startdate><enddate>20210802</enddate><creator>Yi, Xianlin</creator><creator>Liu, Chanzhen</creator><creator>Zhou, Juan</creator><creator>Li, You</creator><creator>Lu, Haoyuan</creator><creator>Lu, Yulei</creator><creator>Wei, Wei</creator><creator>Wu, Mingsong</creator><general>Taylor & Francis</general><scope>DYCCY</scope><scope>PQ8</scope></search><sort><creationdate>20210802</creationdate><title>Supplementary Figure 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing</title><author>Yi, Xianlin ; Liu, Chanzhen ; Zhou, Juan ; Li, You ; Lu, Haoyuan ; Lu, Yulei ; Wei, Wei ; Wu, Mingsong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-datacite_primary_10_25402_rme_150901413</frbrgroupid><rsrctype>images</rsrctype><prefilter>images</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Yi, Xianlin</creatorcontrib><creatorcontrib>Liu, Chanzhen</creatorcontrib><creatorcontrib>Zhou, Juan</creatorcontrib><creatorcontrib>Li, You</creatorcontrib><creatorcontrib>Lu, Haoyuan</creatorcontrib><creatorcontrib>Lu, Yulei</creatorcontrib><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Wu, Mingsong</creatorcontrib><collection>DataCite (Open Access)</collection><collection>DataCite</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yi, Xianlin</au><au>Liu, Chanzhen</au><au>Zhou, Juan</au><au>Li, You</au><au>Lu, Haoyuan</au><au>Lu, Yulei</au><au>Wei, Wei</au><au>Wu, Mingsong</au><format>book</format><genre>unknown</genre><ristype>GEN</ristype><title>Supplementary Figure 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing</title><date>2021-08-02</date><risdate>2021</risdate><abstract>Abstract
Background: This study aimed to investigate the expression of regeneration-related
genes in canine urine during bladder repair. Materials & methods:
Canine urine samples were collected after partial cystectomy. Regenerative mRNA
of hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF),
key stem cell transcription factors, and cholinergic signals were detected. Results:
HIF-1α, VEGF, CD44, interleukin-6, and prominin 1 expression in canine urine
after partial cystectomy exhibited two similar peaks at ~2 weeks. HIF-1α and
VEGF expression was higher in the afternoon than in the morning. The expression
of key stem cell transcription factors and cholinergic signals also exhibited a
rhythm along with bladder healing. Conclusions: The expression of
HIF-1α, VEGF, key stem cell transcription factors, and cholinergic signals
exhibited a time curve distribution during canine bladder healing. The
expression trend of some regenerative genes was similar during bladder healing,
and a cooperative effect may exist.</abstract><pub>Taylor & Francis</pub><doi>10.25402/rme.15090141</doi><oa>free_for_read</oa></addata></record> |
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| title | Supplementary Figure 1: Urine-based regenerative RNA biomarkers for urinary bladder wound healing |
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