One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities

Compounds MNS-1 and MNS-2 were further subjected to reflux for 2 h with the addition of ferric chloride (FeCl3) to produce MNS-3 and MNS-4, respectively (Supplementary Scheme 1).The IR and NMR spectra of all four compounds (MNS-1–MNS-4) showed characteristic peaks that helped to identify the compounds and analyze the success of synthesis (Supplementary Figures 2–13).