Supplementary materials for the manuscript Phenotypic Characteristics and Variability in CHARGE Syndrome: A PRISMA-Compliant Systematic Review and Meta-Analysis

Supplementary Material 1 to accompany the manuscript Phenotypic Characteristics and Variability in CHARGE Syndrome: A PRISMA-Compliant Systematic Review and Meta-Analysis. Supplementary material 1 includes; Appendix 1, PRISMA 2020 checklist; Appendix 2, Detailed search strategy; Appendix 3, Reference list of studies identified through manual searches; Appendix 4, Inclusion and exclusion criteria used for study selection; Appendix 5, Quality appraisal; Appendix 6, Meta-Analysis; Appendix 7, Sensitivity assessments; Appendix 8, Forest plots and sensitivity analysis for diagnostic signs; Appendix 9, Incidence of physical characteristics and conditions associated with CHARGE syndrome reported in the 47 eligible studies; Appendix 10, Forest plots and sensitivity analysis for physical characteristics and conditions; Appendix 11, Details of quality weighted pooled prevalence estimates and subgroup and sensitivity analysis for cognitive, behavioural, psychological and sleep characteristics; Appendix 12, Definitions applied and summary pooled prevalence estimates for behavioural, psychological, cognitive and sleep characteristics in CHARGE syndrome; Appendix 13, Meta-regression estimates of the effects of co-occurring characteristics on behavioural, psychological, cognitive and sleep characteristics in CHARGE syndrome. Statistical significance evaluated using Benjamini-Hochberg adjustment for multiple comparisons; Appendix 14, Meta-regression estimates of genotype phenotype corrolations in CHARGE syndrome. Statistical significance evaluated using Benjamini-Hochberg adjustment for multiple comparisons. Supplementary Material 2 to accompany the manuscript Phenotypic Characteristics and Variability in CHARGE Syndrome: A PRISMA-Compliant Systematic Review and Meta-Analysis. The Supplementary Material 2 file includes the R code used for the meta-analysis, sensitivity analysis, subgroup analysis and meta-regression.