MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo,...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Massó Vallés, Daniel Beaulieu, Marie-Eve Jauset González, Toni Giuntini, Fabio Zacarías-Fluck, Mariano F Foradada, Laia Martínez-Martín, Sandra Serrano, Erika Martín-Fernández, Génesis Casacuberta-Serra, Sílvia Castillo Cano, Virginia Kaur, Jastrinjan López-Estévez, Sergio Morcillo, Miguel Ángel Alzrigat, Mohammad Mahmoud, Loay Luque-García, Antonio Escorihuela, Marta Guzman, Marta Arribas, Joaquín V Serra, Violeta Larsson, Lars-Gunnar Whitfield, Jonathan R Soucek, Laura |
| description | While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability. |
| format | Article |
| fullrecord | <record><control><sourceid>csuc_XX2</sourceid><recordid>TN_cdi_csuc_recercat_oai_recercat_cat_2072_536155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>oai_recercat_cat_2072_536155</sourcerecordid><originalsourceid>FETCH-csuc_recercat_oai_recercat_cat_2072_5361553</originalsourceid><addsrcrecordid>eNqdTLsKwkAQTGMh6j_sB0QwCTF9DjUWAUEbq7DZrMlhuIO7VfHvvYBgbzHMDPOYR1RfFRzNoFst2hqocBQPNQt6QdEEpeMgQaEhdnBytnfs_VRt31COlu7a9HBw9iVDHJ6eOIUxoOngzNyFdBnNbjh6Xn15ESX73UVVa_IPahyHY0JpLOqfmZBuirTJs22S59k_mw8AU0pp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding</title><source>Recercat</source><creator>Massó Vallés, Daniel ; Beaulieu, Marie-Eve ; Jauset González, Toni ; Giuntini, Fabio ; Zacarías-Fluck, Mariano F ; Foradada, Laia ; Martínez-Martín, Sandra ; Serrano, Erika ; Martín-Fernández, Génesis ; Casacuberta-Serra, Sílvia ; Castillo Cano, Virginia ; Kaur, Jastrinjan ; López-Estévez, Sergio ; Morcillo, Miguel Ángel ; Alzrigat, Mohammad ; Mahmoud, Loay ; Luque-García, Antonio ; Escorihuela, Marta ; Guzman, Marta ; Arribas, Joaquín V ; Serra, Violeta ; Larsson, Lars-Gunnar ; Whitfield, Jonathan R ; Soucek, Laura</creator><creatorcontrib>Massó Vallés, Daniel ; Beaulieu, Marie-Eve ; Jauset González, Toni ; Giuntini, Fabio ; Zacarías-Fluck, Mariano F ; Foradada, Laia ; Martínez-Martín, Sandra ; Serrano, Erika ; Martín-Fernández, Génesis ; Casacuberta-Serra, Sílvia ; Castillo Cano, Virginia ; Kaur, Jastrinjan ; López-Estévez, Sergio ; Morcillo, Miguel Ángel ; Alzrigat, Mohammad ; Mahmoud, Loay ; Luque-García, Antonio ; Escorihuela, Marta ; Guzman, Marta ; Arribas, Joaquín V ; Serra, Violeta ; Larsson, Lars-Gunnar ; Whitfield, Jonathan R ; Soucek, Laura</creatorcontrib><description>While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.</description><language>eng</language><creationdate>2022</creationdate><rights>open access Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. https://creativecommons.org/licenses/by/4.0</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,26951</link.rule.ids><linktorsrc>$$Uhttps://recercat.cat/handle/2072/536155$$EView_record_in_Consorci_de_Serveis_Universitaris_de_Catalunya_(CSUC)$$FView_record_in_$$GConsorci_de_Serveis_Universitaris_de_Catalunya_(CSUC)$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Massó Vallés, Daniel</creatorcontrib><creatorcontrib>Beaulieu, Marie-Eve</creatorcontrib><creatorcontrib>Jauset González, Toni</creatorcontrib><creatorcontrib>Giuntini, Fabio</creatorcontrib><creatorcontrib>Zacarías-Fluck, Mariano F</creatorcontrib><creatorcontrib>Foradada, Laia</creatorcontrib><creatorcontrib>Martínez-Martín, Sandra</creatorcontrib><creatorcontrib>Serrano, Erika</creatorcontrib><creatorcontrib>Martín-Fernández, Génesis</creatorcontrib><creatorcontrib>Casacuberta-Serra, Sílvia</creatorcontrib><creatorcontrib>Castillo Cano, Virginia</creatorcontrib><creatorcontrib>Kaur, Jastrinjan</creatorcontrib><creatorcontrib>López-Estévez, Sergio</creatorcontrib><creatorcontrib>Morcillo, Miguel Ángel</creatorcontrib><creatorcontrib>Alzrigat, Mohammad</creatorcontrib><creatorcontrib>Mahmoud, Loay</creatorcontrib><creatorcontrib>Luque-García, Antonio</creatorcontrib><creatorcontrib>Escorihuela, Marta</creatorcontrib><creatorcontrib>Guzman, Marta</creatorcontrib><creatorcontrib>Arribas, Joaquín V</creatorcontrib><creatorcontrib>Serra, Violeta</creatorcontrib><creatorcontrib>Larsson, Lars-Gunnar</creatorcontrib><creatorcontrib>Whitfield, Jonathan R</creatorcontrib><creatorcontrib>Soucek, Laura</creatorcontrib><title>MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding</title><description>While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.</description><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>XX2</sourceid><recordid>eNqdTLsKwkAQTGMh6j_sB0QwCTF9DjUWAUEbq7DZrMlhuIO7VfHvvYBgbzHMDPOYR1RfFRzNoFst2hqocBQPNQt6QdEEpeMgQaEhdnBytnfs_VRt31COlu7a9HBw9iVDHJ6eOIUxoOngzNyFdBnNbjh6Xn15ESX73UVVa_IPahyHY0JpLOqfmZBuirTJs22S59k_mw8AU0pp</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Massó Vallés, Daniel</creator><creator>Beaulieu, Marie-Eve</creator><creator>Jauset González, Toni</creator><creator>Giuntini, Fabio</creator><creator>Zacarías-Fluck, Mariano F</creator><creator>Foradada, Laia</creator><creator>Martínez-Martín, Sandra</creator><creator>Serrano, Erika</creator><creator>Martín-Fernández, Génesis</creator><creator>Casacuberta-Serra, Sílvia</creator><creator>Castillo Cano, Virginia</creator><creator>Kaur, Jastrinjan</creator><creator>López-Estévez, Sergio</creator><creator>Morcillo, Miguel Ángel</creator><creator>Alzrigat, Mohammad</creator><creator>Mahmoud, Loay</creator><creator>Luque-García, Antonio</creator><creator>Escorihuela, Marta</creator><creator>Guzman, Marta</creator><creator>Arribas, Joaquín V</creator><creator>Serra, Violeta</creator><creator>Larsson, Lars-Gunnar</creator><creator>Whitfield, Jonathan R</creator><creator>Soucek, Laura</creator><scope>XX2</scope></search><sort><creationdate>2022</creationdate><title>MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding</title><author>Massó Vallés, Daniel ; Beaulieu, Marie-Eve ; Jauset González, Toni ; Giuntini, Fabio ; Zacarías-Fluck, Mariano F ; Foradada, Laia ; Martínez-Martín, Sandra ; Serrano, Erika ; Martín-Fernández, Génesis ; Casacuberta-Serra, Sílvia ; Castillo Cano, Virginia ; Kaur, Jastrinjan ; López-Estévez, Sergio ; Morcillo, Miguel Ángel ; Alzrigat, Mohammad ; Mahmoud, Loay ; Luque-García, Antonio ; Escorihuela, Marta ; Guzman, Marta ; Arribas, Joaquín V ; Serra, Violeta ; Larsson, Lars-Gunnar ; Whitfield, Jonathan R ; Soucek, Laura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-csuc_recercat_oai_recercat_cat_2072_5361553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Massó Vallés, Daniel</creatorcontrib><creatorcontrib>Beaulieu, Marie-Eve</creatorcontrib><creatorcontrib>Jauset González, Toni</creatorcontrib><creatorcontrib>Giuntini, Fabio</creatorcontrib><creatorcontrib>Zacarías-Fluck, Mariano F</creatorcontrib><creatorcontrib>Foradada, Laia</creatorcontrib><creatorcontrib>Martínez-Martín, Sandra</creatorcontrib><creatorcontrib>Serrano, Erika</creatorcontrib><creatorcontrib>Martín-Fernández, Génesis</creatorcontrib><creatorcontrib>Casacuberta-Serra, Sílvia</creatorcontrib><creatorcontrib>Castillo Cano, Virginia</creatorcontrib><creatorcontrib>Kaur, Jastrinjan</creatorcontrib><creatorcontrib>López-Estévez, Sergio</creatorcontrib><creatorcontrib>Morcillo, Miguel Ángel</creatorcontrib><creatorcontrib>Alzrigat, Mohammad</creatorcontrib><creatorcontrib>Mahmoud, Loay</creatorcontrib><creatorcontrib>Luque-García, Antonio</creatorcontrib><creatorcontrib>Escorihuela, Marta</creatorcontrib><creatorcontrib>Guzman, Marta</creatorcontrib><creatorcontrib>Arribas, Joaquín V</creatorcontrib><creatorcontrib>Serra, Violeta</creatorcontrib><creatorcontrib>Larsson, Lars-Gunnar</creatorcontrib><creatorcontrib>Whitfield, Jonathan R</creatorcontrib><creatorcontrib>Soucek, Laura</creatorcontrib><collection>Recercat</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Massó Vallés, Daniel</au><au>Beaulieu, Marie-Eve</au><au>Jauset González, Toni</au><au>Giuntini, Fabio</au><au>Zacarías-Fluck, Mariano F</au><au>Foradada, Laia</au><au>Martínez-Martín, Sandra</au><au>Serrano, Erika</au><au>Martín-Fernández, Génesis</au><au>Casacuberta-Serra, Sílvia</au><au>Castillo Cano, Virginia</au><au>Kaur, Jastrinjan</au><au>López-Estévez, Sergio</au><au>Morcillo, Miguel Ángel</au><au>Alzrigat, Mohammad</au><au>Mahmoud, Loay</au><au>Luque-García, Antonio</au><au>Escorihuela, Marta</au><au>Guzman, Marta</au><au>Arribas, Joaquín V</au><au>Serra, Violeta</au><au>Larsson, Lars-Gunnar</au><au>Whitfield, Jonathan R</au><au>Soucek, Laura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding</atitle><date>2022</date><risdate>2022</risdate><abstract>While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_csuc_recercat_oai_recercat_cat_2072_536155 |
| source | Recercat |
| title | MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T12%3A09%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-csuc_XX2&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MYC%20Inhibition%20Halts%20Metastatic%20Breast%20Cancer%20Progression%20by%20Blocking%20Growth,%20Invasion,%20and%20Seeding&rft.au=Mass%C3%B3%20Vall%C3%A9s,%20Daniel&rft.date=2022&rft_id=info:doi/&rft_dat=%3Ccsuc_XX2%3Eoai_recercat_cat_2072_536155%3C/csuc_XX2%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |