MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding

While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo,...

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Hauptverfasser: Massó Vallés, Daniel, Beaulieu, Marie-Eve, Jauset González, Toni, Giuntini, Fabio, Zacarías-Fluck, Mariano F, Foradada, Laia, Martínez-Martín, Sandra, Serrano, Erika, Martín-Fernández, Génesis, Casacuberta-Serra, Sílvia, Castillo Cano, Virginia, Kaur, Jastrinjan, López-Estévez, Sergio, Morcillo, Miguel Ángel, Alzrigat, Mohammad, Mahmoud, Loay, Luque-García, Antonio, Escorihuela, Marta, Guzman, Marta, Arribas, Joaquín V, Serra, Violeta, Larsson, Lars-Gunnar, Whitfield, Jonathan R, Soucek, Laura
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Sprache:eng
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Zusammenfassung:While MYC role in metastasis has been long controversial, this manuscript demonstrates that MYC inhibition by either transgenic expression or pharmacologic use of the recombinantly produced Omomyc miniprotein exerts antitumor and antimetastatic activity in breast cancer models in vitro and in vivo, suggesting its clinical applicability.