Effect of polyphenols intake on obesity-induced maternal programming

Fundació Carreras MLR acknowledges support from the Brazilian National Council for Scientific and Tech-nological Development (CNPq, 305402/2019-6). I.M.F. was supported by a scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES, Ministry of Education of Brazil). J.C.S. holds a Sara Borrell research contract from Instituto de Salud Carlos III (CD19/00228). Funding: MLR acknowledges support from the Brazilian National Council for Scientific and Technological Development (CNPq, 305402/2019-6). I.M.F. was supported by a scholarship from the Coordination for the Improvement of Higher Education Personnel (CAPES, Ministry of Education of Brazil). J.C.S. holds a Sara Borrell research contract from Instituto de Salud Carlos III (CD19/00228). Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. This increased risk may also be epigenetically transmitted across generations. Thus, there is an imperative need to find effective reprogramming approaches in order to resume normal fetal development. Polyphenols are bioactive compounds found in vegetables and fruits that exert its anti-obesity effect through its pow-erful anti-oxidant and anti-inflammatory activities. Polyphenol supplementation has been proven to counteract the prejudicial effects of maternal obesity programming on progeny. Indeed, some polyphenols can cross the placenta and protect the fetal predisposition against obesity. The present review summarizes the effects of dietary polyphenols on obesity-induced maternal reprogramming as an offspring anti-obesity approach.