Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis

Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis

Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk of infection. This investigation evaluated prevalence and characteristics of bacterial and fungal infections causing and complicating ACLF, predictors of follow-up bacterial...

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Veröffentlicht in:Gut 2018-10, Vol.67 (10), p.1870-1880
Hauptverfasser: Fernández, Javier, Acevedo, Juan, Wiest, Reiner, Gustot, Thierry, Amoros, Alex, Deulofeu, Carme, Reverter, Enric, Martínez, Javier, Saliba, Faouzi, Jalan, Rajiv, Welzel, Tania, Pavesi, Marco, Hernández-Tejero, María, Ginès, Pere, Arroyo, Vicente
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Bacteria
Bacterial infections
Chronic diseases
Chronic infection
Diagnosis
Fluids
Fungal infections
Gastroenterology
Hepatitis
Hepatology
Hypotheses
Immunotherapy
Infeccions
Infections
Inflammation
Intensive care
Liver
Liver diseases
Liver failure
Malalties cròniques
Malalties del fetge
Medical prognosis
Microbiology
Mortality
Multiple organ dysfunction syndrome
Nosocomial infection
Nosocomial infections
Peritonitis
Pneumonia
Prognosis
Pronòstic mèdic
Sepsis
Survival
Systematic review
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Zusammenfassung:Bacterial infection is a frequent trigger of acute-on-chronic liver failure (ACLF), syndrome that could also increase the risk of infection. This investigation evaluated prevalence and characteristics of bacterial and fungal infections causing and complicating ACLF, predictors of follow-up bacterial infections and impact of bacterial infections on survival.Patients407 patients with ACLF and 235 patients with acute decompensation (AD).Results152 patients (37%) presented bacterial infections at ACLF diagnosis; 46%(n=117) of the remaining 255 patients with ACLF developed bacterial infections during follow-up (4 weeks). The corresponding figures in patients with AD were 25% and 18% (p
ISSN:0017-5749
1468-3288
DOI:10.1136/gutjnl-2017-314240