Effects of thermoregulation on human sleep patterns: A mathematical model of sleep-wake cycles with REM-NREM subcircuit

In this paper we construct a mathematical model of human sleep/wake regulation with thermoregulation and temperature e ects. Simulations of this model show features previously presented in experimental data such as elongation of duration and number of REM bouts across the night as well as the appear...

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Hauptverfasser:	Bañuelos, Selenne, Best, Janet, Huguet Casades, Gemma, Prieto-Langarica, Alicia, Pyzza, Pamela, Schmidt, Markus, Wilson, Shelby
Format:	Text Resource
Sprache:	eng
Schlagworte:	92 Biology and other natural sciences 92B Mathematical biology in general 92C Physiological, cellular and medical topics Classificació AMS Matemàtiques i estadística Models matemàtics REM cycle sleep thermoregulation Trastorns del son Àrees temàtiques de la UPC
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Beschreibung
Zusammenfassung:	In this paper we construct a mathematical model of human sleep/wake regulation with thermoregulation and temperature e ects. Simulations of this model show features previously presented in experimental data such as elongation of duration and number of REM bouts across the night as well as the appearance of awakenings due to deviations in body temperature from thermoneutrality. This model helps to demonstrate the importance of temperature in the sleep cycle. Further modi cations of the model to include more temperature e ects on other aspects of sleep regulation such as sleep and REM latency are discussed