Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and...

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Hauptverfasser: Berndt, Sonja I, Camp, Nicola J, Skibola, Christine F, Vijai, Joseph, Wang, Zhaoming, Gu, Jian, Nieters, Alexandra, Kelly, Rachel S, Smedby, Karin E, Cozen, Wendy, Allmer, Cristine, Hjalgrim, Henrik, Melbye, Mads, Glenn, Martha, Cannon-Albright, Lisa A, Chaffee, Kari G, Zhi, Degui, Diver, W. Ryan, Link, Brian K, Bracci, Paige M, Riby, Jacques, Arnett, Donna K, Caporaso, Neil E, Leach, Justin M, Jackson, Rebecca D, Brennan, Paul, Tinker, Lesley F, Casabonne, Delphine, Becker, Nikolaus, Chirlaque, María Dolores, Foretova, Lenka, MCkay, James, Staines, Anthony, Achenbach, Sara J, Vachon, Celine M, Goldin, Lynn R, Zheng, Tongzhang, Severson, Richard K, Strom, Sara S, Norman, Aaron D, Roos, Anneclaire J. De, Morton, Lindsay M, Bertrand, Kimberly A, Vineis, Paolo, Kaaks, Rudolf, Milne, Roger L, Connors, Joseph M, Travis, Ruth C, Huang, Jinyan, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Wu, Xifeng, Turner, Jenny, Spinelli, John J, Gascoyne, Randy D, Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Wang, Sophia S, Ennas, Maria Grazia, Ferri, Giovanni M, North, Kari E, Liang, Liming, Cox, Angela, Crouch, Simon, Park, Ju-Hyun, Chatterjee, Nilanjan, Snowden, John A, Wright, Josh, Fraumeni, Joseph F, Offit, Kenneth, Sanjosé Llongueras, Silvia de, Cerhan, James R, Chanock, Stephen J, Novak, Anne J, Yeager, Meredith, Rothman, Nathaniel, Slager, Susan L, Lan, Qing, Teras, Lauren R, Machado, Moara, Shanafelt, Tait D, Brooks-Wilson, Angela R, Hartge, Patricia, Purdue, Mark P, Montalvan, Rebecca, Birmann, Brenda M, Vajdic, Claire M, Giles, Graham G, Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Burdett, Laurie, Hutchinson, Amy, Ye, Yuanqing, Call, Timothy G, Kay, Neil E, Liebow, Mark, Cunningham, Julie M
Format: Artikel
Sprache:eng
Schlagworte:
Chronic lymphocytic leukemia
Genetic disorders
Leucèmia limfocítica crònica
Malalties hereditàries
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Zusammenfassung:Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P