Withdrawing inactive NRTIs in HIV-1 subjects with suppressed viraemia: a randomized trial

Extensively pretreated subjects with virological failure (VF) may receive salvage regimens containing NRTIs with only residual or no activity. Once virological suppression is achieved, their contribution remains elusive. This was a multicentre, randomized, prospective study. Subjects with at least o...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2016-05, Vol.71 (5), p.1346-1351
Hauptverfasser:	Llibre, Josep M, Alvarez, Hortensia, Antela, Antonio, Toro, Jessica, Payeras, Antoni, Pérez-Elías, M Jesús, Imaz, Arkaitz, Masià, Mar, Pérez-Alvarez, Núria, Burgos, Joaquin, Clotet, Bonaventura
Format:	Artikel
Sprache:	eng
Schlagworte:	90 Operations research, mathematical programming Adult Aged Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Classificació AMS Drug resistance Drug-Related Side Effects and Adverse Reactions Female HIV HIV Infections - drug therapy HIV-1 - isolation & purification Human immunodeficiency virus Humans Investigació operativa Male Matemàtiques i estadística Medical treatment Middle Aged Mutation Prospective Studies Ribonucleic acid RNA Salvage Therapy - adverse effects Salvage Therapy - methods Treatment Outcome Viral Load Withholding Treatment Àrees temàtiques de la UPC
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Zusammenfassung:	Extensively pretreated subjects with virological failure (VF) may receive salvage regimens containing NRTIs with only residual or no activity. Once virological suppression is achieved, their contribution remains elusive. This was a multicentre, randomized, prospective study. Subjects with at least one prior VF, HIV-1 RNA
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dkv461