An unidentified cluster of infection in the Peruvian Amazon region

Bartonella bacilliformis is the etiological agent of Carrion's disease, which is a neglected disease linked to people in low-socioeconomic populations in Andean valleys. An outbreak of B. bacilliformis was reported in a rural area of the Peruvian Amazon region. The aim of this study was to char...

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Veröffentlicht in:Journal of infection in developing countries 2015-05, Vol.9 (5), p.524-529
Hauptverfasser: Cornejo, Angela, Gomes, Claudia, Suarez, Luis, Martinez-Puchol, Sandra, Bustamante, Pershing, Pons, Maria J, Ruiz, Joaquim, Del Valle Mendoza, Juana
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container_end_page 529
container_issue 5
container_start_page 524
container_title Journal of infection in developing countries
container_volume 9
creator Cornejo, Angela
Gomes, Claudia
Suarez, Luis
Martinez-Puchol, Sandra
Bustamante, Pershing
Pons, Maria J
Ruiz, Joaquim
Del Valle Mendoza, Juana
description Bartonella bacilliformis is the etiological agent of Carrion's disease, which is a neglected disease linked to people in low-socioeconomic populations in Andean valleys. An outbreak of B. bacilliformis was reported in a rural area of the Peruvian Amazon region. The aim of this study was to characterize this outbreak using molecular techniques. Fifty-three blood samples from patients diagnosed with Carrion's disease were analyzed by molecular tools, using both a Bartonella-specific polymerase chain reaction (PCR) and an universal PCR, both based on 16S rRNA gene amplification. Additional water samples from the area were also analyzed. Unexpectedly, the samples were positive only when the universal PCR was used. Although environmental contamination cannot be ruled out, the results showed that Sphingomonas faeni was the possible causative agent of this outbreak, and that water was the most feasible infection source. Diagnosis by clinical criteria or microscopy may lead to misdiagnosis. There is a need to include molecular tools in the routine diagnosis of febrile syndromes, including Carrion's disease.
doi_str_mv 10.3855/jidc.6235
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An outbreak of B. bacilliformis was reported in a rural area of the Peruvian Amazon region. The aim of this study was to characterize this outbreak using molecular techniques. Fifty-three blood samples from patients diagnosed with Carrion's disease were analyzed by molecular tools, using both a Bartonella-specific polymerase chain reaction (PCR) and an universal PCR, both based on 16S rRNA gene amplification. Additional water samples from the area were also analyzed. Unexpectedly, the samples were positive only when the universal PCR was used. Although environmental contamination cannot be ruled out, the results showed that Sphingomonas faeni was the possible causative agent of this outbreak, and that water was the most feasible infection source. Diagnosis by clinical criteria or microscopy may lead to misdiagnosis. 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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Recercat
subjects Adolescent
Adult
Aged
Aged, 80 and over
Aigua
Bacteris patògens
Blood - microbiology
Child
Child, Preschool
Disease Outbreaks
DNA, Bacterial - genetics
DNA, Ribosomal - genetics
Female
Gene amplification
Gram-Negative Bacterial Infections - diagnosis
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Humans
Infant
Male
Middle Aged
Parasites
Paràsits
Pathogenic bacteria
Peru
Peru - epidemiology
Perú
Polymerase Chain Reaction
Reacció en cadena de la polimerasa
RNA, Ribosomal, 16S - genetics
Rural Population
Sphingomonas - classification
Sphingomonas - genetics
Sphingomonas - isolation & purification
Water
Water Microbiology
Young Adult
title An unidentified cluster of infection in the Peruvian Amazon region
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