Model Studies on the Synthesis of Madangamine Alkaloids. Assembly of the Macrocyclic Rings

Model Studies on the Synthesis of Madangamine Alkaloids. Assembly of the Macrocyclic Rings

Using simplified model derivatives, the assembly of the macrocyclic rings of madangamines, including the 13- and 14-membered D rings of madangamines C–E, the all-cis-triunsaturated 15-membered D ring of madangamine A, and the (Z,Z)-unsaturated 11-membered E ring common to madangamines A–E, has been...

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Veröffentlicht in:Organic letters 2012-08, Vol.14 (15), p.3916-3919
Hauptverfasser: Proto, Stefano, Amat, Mercedes, Pérez, Maria, Ballette, Roberto, Romagnoli, Federica, Mancinelli, Andrea, Bosch, Joan
Format: Artikel
Sprache:eng
Schlagworte:
Alcaloides
Alkaloids
Alkaloids - chemical synthesis
Alkaloids - chemistry
Chemical processes
Compostos heterocíclics
Cyclization
Heterocyclic compounds
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemistry
Models moleculars
Models, Molecular
Molecular models
Molecular Structure
Processos químics
Stereoisomerism
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Zusammenfassung:Using simplified model derivatives, the assembly of the macrocyclic rings of madangamines, including the 13- and 14-membered D rings of madangamines C–E, the all-cis-triunsaturated 15-membered D ring of madangamine A, and the (Z,Z)-unsaturated 11-membered E ring common to madangamines A–E, has been studied.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol301672y