Efficacy of Oral Artemisinin and Praziquantel Chemotherapy on Schistosoma mansoni Infected Mice by Means of Parasitological Parameters

Aim: Praziquantel-based chemotherapy is generally effective in the control of morbidity, decline in the prevalence and intensity of Schistosoma mansoni infections. Nevertheless, the potential emergence of praziquantel resistance in S. mansoni posses danger in the elimination of this neglected tropical disease in Africa. Therefore, this study was designed to evaluate the in-vivo efficacy of Praziquantel and Artemisinin using mice infected with S. Mansoni cercariae. Methods: Infected mice with S. mansoni were treated with different doses of Artemisinin and Praziquantel from day 42 post infection to assess its efficacy on adult worms and eggs. A 2-day Protocol: artemisinin 400 mg/kg with Praziquantel of 500 mg/kg daily, 4-day protocol: artemisinin 200 mg/kg with praziquantel of 250 mg/kg daily, 6-day protocol: artemisinin 100 mg/kg with praziquantel of 125 mg/kg daily were used. A value of p