Pyloricidins, Novel Anti-Helicobacter pylori Antibiotics Produced by Bacillus sp: I. Taxonomy, Fermentation and Biological Activity

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolia...

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Veröffentlicht in:	Journal of antibiotics 2001/11/25, Vol.54(11), pp.926-933
Hauptverfasser:	NAKAO, MASAFUMI, MIYAGAWA, KEN-ICHIRO, NAKANO, YOSHITAKA, SAKANE, TAKESHI, TADA, MAYUMI, NISHIMURA, OSAMU, FUJINO, MASAHIKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antibiotics. Antiinfectious agents. Antiparasitic agents Applied microbiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Medical sciences Microbiology Pharmacology. Drug treatments
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Zusammenfassung:	Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H, pylori infection as a single agent.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.54.926