Cytokine Production Inhibitors Produced by a Fungus, Oidiodendron griseum

A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271α, LL-Z1271γ, CJ-14, 445, PR 1388, CJ-14, 604 and a new diterpene, CJ-14, 515. They inhibited both lipopolysaccharide-induced interleukin-1β and tumor...

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Veröffentlicht in:	Journal of antibiotics 2001/09/25, Vol.54(9), pp.697-702
Hauptverfasser:	ICHIKAWA, KATSUOMI, HIRAI, HIDEO, ISHIGURO, MASARU, KAMBARA, TAKAHITO, KATO, YOSHINAO, KIM, YOON JEONG, KOJIMA, YASUHIRO, MATSUNAGA, YASUE, NISHIDA, HIROYUKI, SHIOMI, YUKIO, YOSHIKAWA, NOBUJI, HUANG, LLANG HSIUNG, KOJIMA, NAKAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascomycota - classification Ascomycota - growth & development Ascomycota - metabolism Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - metabolism Diterpenes - pharmacology Fundamental and applied biological sciences. Psychology General aspects Humans Inhibitory Concentration 50 Interleukin-1 - biosynthesis Interleukin-1 - blood Leucine - metabolism Microbiology Pyrones - chemistry Pyrones - isolation & purification Pyrones - metabolism Pyrones - pharmacology Terpenes - chemistry Terpenes - isolation & purification Terpenes - metabolism Terpenes - pharmacology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271α, LL-Z1271γ, CJ-14, 445, PR 1388, CJ-14, 604 and a new diterpene, CJ-14, 515. They inhibited both lipopolysaccharide-induced interleukin-1β and tumor necrosis factor-α production in human whole blood with IC50s of the range from 0.049 to 100 μM.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.54.697