Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity: II. Structure Determination

Neuroprotectins A and B, Bicyclohexapeptides Protecting Chick Telencephalic Neurons from Excitotoxicity: II. Structure Determination

In the course of our search for neuroprotective agents of microbial origin against kainateinduced neurotoxicity, we have succeeded in the isolation of two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound, complestatin, from the fermentation broth of Streptomyces sp. Q...

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Veröffentlicht in:Journal of antibiotics 2001/12/25, Vol.54(12), pp.1019-1024
Hauptverfasser: KOBAYASHI, HIROYUKI, SHIN-YA, KAZUO, FURIHATA, KAZUO, NAGAI, KOJI, SUZUKI, KEN-ICHI, HAYAKAWA, YOICHI, SETO, HARUO, YUN, BONG-SIK, RYOO, IN-JA, KIM, JUNG-SIK, KIM, CHANG-JIN, YOO, ICK-DONG
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Medical sciences
Molecular Structure
Neuropharmacology
Neuroprotective agent
Neuroprotective Agents - chemistry
Oligopeptides - chemistry
Pharmacology. Drug treatments
Stereoisomerism
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Zusammenfassung:In the course of our search for neuroprotective agents of microbial origin against kainateinduced neurotoxicity, we have succeeded in the isolation of two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound, complestatin, from the fermentation broth of Streptomyces sp. Q27107. They are closely related in structure to complestatin and possess an oxindolylalanine moiety in place of the tryptophan residue present in complestatin.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.54.1019