NF00659A1, A2, A3, B1 and B2, Novel Antitumor Antibiotics Produced by Aspergillus sp. NF 00659: II. Structural Elucidation

NF00659A1, A2, A3, B1 and B12, having insecticidal and antitumor activities, were isolated from a culture mycelium of Aspergillus sp. NF 00659. The novel structure of NF00659s were determined mainly by spectroscopic studies including various NMR measurements. NF00659s have a common structure which c...

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Veröffentlicht in:	Journal of antibiotics 1997/04/25, Vol.50(4), pp.318-324
Hauptverfasser:	SUZUKI, KATSUHIRO, KUWAHARA, ATSUSHI, NISHIKIORI, TAKAAKI, NAKAGAWA, TAIZO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic agents Applied microbiology Biological and medical sciences Chemotherapic agents Chemotherapy Diterpenes - chemistry Fundamental and applied biological sciences. Psychology Insecticides - chemistry Magnetic Resonance Spectroscopy Medical sciences Microbiology Molecular Structure Pharmacology. Drug treatments Pyrones - chemistry
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Beschreibung
Zusammenfassung:	NF00659A1, A2, A3, B1 and B12, having insecticidal and antitumor activities, were isolated from a culture mycelium of Aspergillus sp. NF 00659. The novel structure of NF00659s were determined mainly by spectroscopic studies including various NMR measurements. NF00659s have a common structure which consists of acyl, α-pyrone and 4, 5-seco-tricyclic diterpene moieties.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.50.318