STUDIES ON NEW ANTIBIOTICS SF2415: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

STUDIES ON NEW ANTIBIOTICS SF2415: I. TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES

A new species of Streptomyces is described for which the name Streptomyces aculeolatus is proposed. The organism produces new antibiotics SF2415A1, A2, A3, Bl, B2 and B3 active against Gram-positive bacteria. Empirical molecular formulae of the antibiotics SF2415A1, A2, A3, Bl, B2 and B3 were determ...

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Veröffentlicht in:Journal of antibiotics 1987/06/25, Vol.40(6), pp.732-739
Hauptverfasser: SHOMURA, TAKASHI, GOMI, SHUICHI, ITO, MITSUGU, YOSHIDA, JUNKO, TANAKA, ERIKO, AMANO, SHOICHI, WATABE, HIRO-OMI, OHUCHI, SHOKICHI, ITOH, JIRO, SEZAKI, MASAJI, TAKEBE, HIDEHI, UOTANI, KAZUMICHI
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Bacterial Agents
Antibacterial agents
Antibiotics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Biotechnology
Chemical Phenomena
Chemistry, Physical
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Kinetics
Lethal Dose 50
Mass Spectrometry
Medical sciences
Mice
Naphthoquinones - biosynthesis
Naphthoquinones - isolation & purification
Naphthoquinones - pharmacology
Pharmacology. Drug treatments
Production of active biomolecules
Spectrophotometry
Streptomyces - classification
Streptomyces - isolation & purification
Streptomyces - metabolism
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Zusammenfassung:A new species of Streptomyces is described for which the name Streptomyces aculeolatus is proposed. The organism produces new antibiotics SF2415A1, A2, A3, Bl, B2 and B3 active against Gram-positive bacteria. Empirical molecular formulae of the antibiotics SF2415A1, A2, A3, Bl, B2 and B3 were determined to be C26H31N2O5Cl, C26H30N2O5, C26H30N2O5Cl2, C26H33O5Cl, C26H32O5 and C26H32O5C12, respectively.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.732