ENHANCEMENT OF 5-FLUOROURACIL UPTAKE INTO THE BACTERIAL CELL BY PIPERACILLIN
The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a β-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount...
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| Veröffentlicht in: | Journal of antibiotics 1986, Vol.39(8), pp.1167-1171 |
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| container_end_page | 1171 |
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| container_issue | 8 |
| container_start_page | 1167 |
| container_title | Journal of antibiotics |
| container_volume | 39 |
| creator | TAKAHATA, MASAHIRO YAMASHIRO, YOSHIKO YOTSUJI, AKIRA FUKUOKA, YOSHIKAZU YASUDA, TAKASHI SAIKAWA, ISAMU UEDA, YASUSHI |
| description | The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a β-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount of piperacillin bound to penicillin binding protein (PBP) did not change when 5-fluorouracil was added. The morphological change of the cell was due to the 5-fluorouracil when synergism appeared between 5-fluorouracil and piperacillin. |
| doi_str_mv | 10.7164/antibiotics.39.1167 |
| format | Article |
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It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount of piperacillin bound to penicillin binding protein (PBP) did not change when 5-fluorouracil was added. The morphological change of the cell was due to the 5-fluorouracil when synergism appeared between 5-fluorouracil and piperacillin.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.39.1167</identifier><identifier>PMID: 3759666</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteria - drug effects ; Bacteria - metabolism ; Bacterial Proteins ; Biological and medical sciences ; Carrier Proteins - metabolism ; Drug Synergism ; Fluorouracil - metabolism ; Fluorouracil - pharmacology ; Hexosyltransferases ; Medical sciences ; Muramoylpentapeptide Carboxypeptidase - metabolism ; Penicillin-Binding Proteins ; Peptidyl Transferases ; Pharmacology. Drug treatments ; Piperacillin - metabolism ; Piperacillin - pharmacology</subject><ispartof>The Journal of Antibiotics, 1986, Vol.39(8), pp.1167-1171</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-dd93cedf4752293b6c89e40e6be5164c28d1f6fa2af9c7d37fc7732062efddb53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8812216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3759666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKAHATA, MASAHIRO</creatorcontrib><creatorcontrib>YAMASHIRO, YOSHIKO</creatorcontrib><creatorcontrib>YOTSUJI, AKIRA</creatorcontrib><creatorcontrib>FUKUOKA, YOSHIKAZU</creatorcontrib><creatorcontrib>YASUDA, TAKASHI</creatorcontrib><creatorcontrib>SAIKAWA, ISAMU</creatorcontrib><creatorcontrib>UEDA, YASUSHI</creatorcontrib><title>ENHANCEMENT OF 5-FLUOROURACIL UPTAKE INTO THE BACTERIAL CELL BY PIPERACILLIN</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a β-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount of piperacillin bound to penicillin binding protein (PBP) did not change when 5-fluorouracil was added. The morphological change of the cell was due to the 5-fluorouracil when synergism appeared between 5-fluorouracil and piperacillin.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - metabolism</subject><subject>Bacterial Proteins</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - metabolism</subject><subject>Drug Synergism</subject><subject>Fluorouracil - metabolism</subject><subject>Fluorouracil - pharmacology</subject><subject>Hexosyltransferases</subject><subject>Medical sciences</subject><subject>Muramoylpentapeptide Carboxypeptidase - metabolism</subject><subject>Penicillin-Binding Proteins</subject><subject>Peptidyl Transferases</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperacillin - metabolism</subject><subject>Piperacillin - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAUhS0EKqXwCxCSB9YUPxo7HtPIpREmqap0YIocx4ZUfaC4DPx7ElpVXa6H8517rg8AjxiNOWaTF707NFWzPzTGj6kYY8z4FRjiKMIBnjBxDYYIERxEEUG34M77NUKUUx4NwIDyUDDGhkDJbB5niXyXWQHzGQyDmVrly3y1jJNUwdWiiN8kTLMih8VcwmmcFHKZxgomUik4_YCLdCH_WZVm9-DG6Y23D6d3BFYzWSTzQOWvaRKrwIRIHIK6FtTY2k14SIigFTORsBNkWWXD7l-GRDV2zGminTC8ptwZzilBjFhX11VIR4Ae95p2731rXfndNlvd_pYYlX015UU1JRVlX03nejq6vn-qra3PnlMXnf580rU3euNavTONP2NdrYTgHlNHbO0P-tOedd12aRt7GY0Fi_r40-ivOGPmS7el3dE_lmCEiw</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>TAKAHATA, MASAHIRO</creator><creator>YAMASHIRO, YOSHIKO</creator><creator>YOTSUJI, AKIRA</creator><creator>FUKUOKA, YOSHIKAZU</creator><creator>YASUDA, TAKASHI</creator><creator>SAIKAWA, ISAMU</creator><creator>UEDA, YASUSHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1986</creationdate><title>ENHANCEMENT OF 5-FLUOROURACIL UPTAKE INTO THE BACTERIAL CELL BY PIPERACILLIN</title><author>TAKAHATA, MASAHIRO ; YAMASHIRO, YOSHIKO ; YOTSUJI, AKIRA ; FUKUOKA, YOSHIKAZU ; YASUDA, TAKASHI ; SAIKAWA, ISAMU ; UEDA, YASUSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-dd93cedf4752293b6c89e40e6be5164c28d1f6fa2af9c7d37fc7732062efddb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - metabolism</topic><topic>Bacterial Proteins</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - metabolism</topic><topic>Drug Synergism</topic><topic>Fluorouracil - metabolism</topic><topic>Fluorouracil - pharmacology</topic><topic>Hexosyltransferases</topic><topic>Medical sciences</topic><topic>Muramoylpentapeptide Carboxypeptidase - metabolism</topic><topic>Penicillin-Binding Proteins</topic><topic>Peptidyl Transferases</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperacillin - metabolism</topic><topic>Piperacillin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKAHATA, MASAHIRO</creatorcontrib><creatorcontrib>YAMASHIRO, YOSHIKO</creatorcontrib><creatorcontrib>YOTSUJI, AKIRA</creatorcontrib><creatorcontrib>FUKUOKA, YOSHIKAZU</creatorcontrib><creatorcontrib>YASUDA, TAKASHI</creatorcontrib><creatorcontrib>SAIKAWA, ISAMU</creatorcontrib><creatorcontrib>UEDA, YASUSHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKAHATA, MASAHIRO</au><au>YAMASHIRO, YOSHIKO</au><au>YOTSUJI, AKIRA</au><au>FUKUOKA, YOSHIKAZU</au><au>YASUDA, TAKASHI</au><au>SAIKAWA, ISAMU</au><au>UEDA, YASUSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ENHANCEMENT OF 5-FLUOROURACIL UPTAKE INTO THE BACTERIAL CELL BY PIPERACILLIN</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1986</date><risdate>1986</risdate><volume>39</volume><issue>8</issue><spage>1167</spage><epage>1171</epage><pages>1167-1171</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a β-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount of piperacillin bound to penicillin binding protein (PBP) did not change when 5-fluorouracil was added. The morphological change of the cell was due to the 5-fluorouracil when synergism appeared between 5-fluorouracil and piperacillin.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>3759666</pmid><doi>10.7164/antibiotics.39.1167</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1986, Vol.39(8), pp.1167-1171 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_crossref_primary_10_7164_antibiotics_39_1167 |
| source | J-STAGE Free; MEDLINE |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Bacteria - metabolism Bacterial Proteins Biological and medical sciences Carrier Proteins - metabolism Drug Synergism Fluorouracil - metabolism Fluorouracil - pharmacology Hexosyltransferases Medical sciences Muramoylpentapeptide Carboxypeptidase - metabolism Penicillin-Binding Proteins Peptidyl Transferases Pharmacology. Drug treatments Piperacillin - metabolism Piperacillin - pharmacology |
| title | ENHANCEMENT OF 5-FLUOROURACIL UPTAKE INTO THE BACTERIAL CELL BY PIPERACILLIN |
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