ENHANCEMENT OF 5-FLUOROURACIL UPTAKE INTO THE BACTERIAL CELL BY PIPERACILLIN

The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a β-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(8), pp.1167-1171
Hauptverfasser:	TAKAHATA, MASAHIRO, YAMASHIRO, YOSHIKO, YOTSUJI, AKIRA, FUKUOKA, YOSHIKAZU, YASUDA, TAKASHI, SAIKAWA, ISAMU, UEDA, YASUSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Bacteria - metabolism Bacterial Proteins Biological and medical sciences Carrier Proteins - metabolism Drug Synergism Fluorouracil - metabolism Fluorouracil - pharmacology Hexosyltransferases Medical sciences Muramoylpentapeptide Carboxypeptidase - metabolism Penicillin-Binding Proteins Peptidyl Transferases Pharmacology. Drug treatments Piperacillin - metabolism Piperacillin - pharmacology
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Zusammenfassung:	The antibacterial activity of 5-fluorouracil, an antineoplastic agent, was found to be enhanced by piperacillin, a β-lactam antibiotic, resulting in a synergism. It was considered that the synergism was caused by an increase of 5-fluorouracil uptake into the bacterial cell. On the other hand, amount of piperacillin bound to penicillin binding protein (PBP) did not change when 5-fluorouracil was added. The morphological change of the cell was due to the 5-fluorouracil when synergism appeared between 5-fluorouracil and piperacillin.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1167