FUNICULOSIN, A NEW ANTIBIOTIC: II. STRUCTURE ELUCIDATION AND ANTIFUNGAL ACTIVITY

Structure elucidation and some biological properties of an antiviral and antifungal antibiotic, funiculosin, are summarized. Funiculosin is a derivative of N-methyl-4-hydroxy-3, 5- disubstituted-2-pyridone containing a novel substituent, cyclopentanetetrol moiety, that is reported here for the first...

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Veröffentlicht in:	Journal of antibiotics 1978, Vol.31(6), pp.533-538
Hauptverfasser:	ANDO, KUNIO, MATSUURA, IKUTOSHI, NAWATA, YOSHIHARU, ENDO, HISAO, SASAKI, HIROSHI, OKYTOMI, TSUNEO, SAEHI, TETSUJI, TAMURA, GAKUZO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Chemical Phenomena Chemistry Guinea Pigs Lethal Dose 50 Mice Models, Molecular Pyridones - pharmacology Pyridones - therapeutic use Rabbits Rats Tinea - prevention & control
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Beschreibung
Zusammenfassung:	Structure elucidation and some biological properties of an antiviral and antifungal antibiotic, funiculosin, are summarized. Funiculosin is a derivative of N-methyl-4-hydroxy-3, 5- disubstituted-2-pyridone containing a novel substituent, cyclopentanetetrol moiety, that is reported here for the first time in a natural product. The antibiotic protects guinea pigs efficiently against experimental trichophytosis. Toxicity of funiculosin is unique and highly selective for animal species.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.31.533