A NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION
AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice)...
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| Veröffentlicht in: | Journal of antibiotics 1977, Vol.30(4), pp.275-282 |
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| container_end_page | 282 |
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| container_issue | 4 |
| container_start_page | 275 |
| container_title | Journal of antibiotics |
| container_volume | 30 |
| creator | OMURA, SATOSHI IWAI, YUZURU HIRANO, ATSUSHI NAKAGAWA, AKIRA AWAYA, JUICHI TSUCHIYA, HISAE TAKAHASHI, YOKO ASUMA, ROKUROU |
| description | AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed. |
| doi_str_mv | 10.7164/antibiotics.30.275 |
| format | Article |
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Antibiot.</addtitle><description>AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.</description><subject>Alkaloids - biosynthesis</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Animals</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Fermentation</subject><subject>Lethal Dose 50</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Streptomyces - classification</subject><subject>Streptomyces - metabolism</subject><subject>Time Factors</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS3Eqzx-ALHwB5AythPHXVppClbzQGkQlE1kpw60akuVhAV_T2hQxWbuaO7cs7gI3RAY-oS793rbLs3ys12WzZDBkPreERoQIYhDXD46RgMAShwhKJyji6ZZATCf-eIMnQreqRigncRJ-IJlNJVRqsZYxg6lguJ0gmd5Fj7laTwPwhlOM_WgEpzL1zTpTnd4EmZxmOQyV2lyh9UsjfYrlskYP2VhpGKVyGyOg0eZySAPM_W2f7hCJ5VeN_b6Ty_R8yTMg0cnSh9UICOndH2vdTQxwhLNrAvGE8yruBYAI82p4O4IOC8XTCwMVC7TwlZgqGtMFyW6NBwYsEtEe25ZfzZNbatiVy83uv4uCBS_5RX_yisYFF15Xei2D-2-zMYuDpG-rc6e9vaqafW7Pdi67iBr-59IRlz8Ut1-dPDDV_mh68Ju2Q8e94AB</recordid><startdate>19770101</startdate><enddate>19770101</enddate><creator>OMURA, SATOSHI</creator><creator>IWAI, YUZURU</creator><creator>HIRANO, ATSUSHI</creator><creator>NAKAGAWA, AKIRA</creator><creator>AWAYA, JUICHI</creator><creator>TSUCHIYA, HISAE</creator><creator>TAKAHASHI, YOKO</creator><creator>ASUMA, ROKUROU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19770101</creationdate><title>A NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION</title><author>OMURA, SATOSHI ; IWAI, YUZURU ; HIRANO, ATSUSHI ; NAKAGAWA, AKIRA ; AWAYA, JUICHI ; TSUCHIYA, HISAE ; TAKAHASHI, YOKO ; ASUMA, ROKUROU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-a1b8e1a3e40b5835f6a8009a628649066cd38db0f43a8ef0b24bbc471acb60303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Alkaloids - biosynthesis</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Animals</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Fermentation</topic><topic>Lethal Dose 50</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Streptomyces - classification</topic><topic>Streptomyces - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OMURA, SATOSHI</creatorcontrib><creatorcontrib>IWAI, YUZURU</creatorcontrib><creatorcontrib>HIRANO, ATSUSHI</creatorcontrib><creatorcontrib>NAKAGAWA, AKIRA</creatorcontrib><creatorcontrib>AWAYA, JUICHI</creatorcontrib><creatorcontrib>TSUCHIYA, HISAE</creatorcontrib><creatorcontrib>TAKAHASHI, YOKO</creatorcontrib><creatorcontrib>ASUMA, ROKUROU</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OMURA, SATOSHI</au><au>IWAI, YUZURU</au><au>HIRANO, ATSUSHI</au><au>NAKAGAWA, AKIRA</au><au>AWAYA, JUICHI</au><au>TSUCHIYA, HISAE</au><au>TAKAHASHI, YOKO</au><au>ASUMA, ROKUROU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1977-01-01</date><risdate>1977</risdate><volume>30</volume><issue>4</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>863788</pmid><doi>10.7164/antibiotics.30.275</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1977, Vol.30(4), pp.275-282 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_crossref_primary_10_7164_antibiotics_30_275 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Alkaloids - biosynthesis Alkaloids - isolation & purification Alkaloids - pharmacology Animals Chemical Phenomena Chemistry Fermentation Lethal Dose 50 Mice Microbial Sensitivity Tests Streptomyces - classification Streptomyces - metabolism Time Factors |
| title | A NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION |
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