A NEW ALKALOID AM-2282 OF STREPTOMYCES ORIGIN TAXONOMY, FERMENTATION, ISOLATION AND PRELIMINARY CHARACTERIZATION

AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice)...

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Veröffentlicht in:	Journal of antibiotics 1977, Vol.30(4), pp.275-282
Hauptverfasser:	OMURA, SATOSHI, IWAI, YUZURU, HIRANO, ATSUSHI, NAKAGAWA, AKIRA, AWAYA, JUICHI, TSUCHIYA, HISAE, TAKAHASHI, YOKO, ASUMA, ROKUROU
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - biosynthesis Alkaloids - isolation & purification Alkaloids - pharmacology Animals Chemical Phenomena Chemistry Fermentation Lethal Dose 50 Mice Microbial Sensitivity Tests Streptomyces - classification Streptomyces - metabolism Time Factors
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Beschreibung
Zusammenfassung:	AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.30.275