NANAOMYCINS, NEW ANTIBIOTICS PRODUCED BY A STRAIN OF STREPTOMYCES: I. TAXONOMY, ISOLATION, CHARACTERIZATION AND BIOLOGICAL PROPERTIES

Nanaomycins are new antibiotics produced by the strain OS-3966 which was designated Streptomyces rosa var. notoensis. Nanaomycins A and B were isolated from the culture filtrate by extraction with organic solvent and silica gel chromatography. The physical and chemical properties suggest that nanaom...

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Veröffentlicht in:	Journal of antibiotics 1975, Vol.28(11), pp.860-867
Hauptverfasser:	TANAKA, HARUO, KOYAMA, YASUAKI, AWAYA, JUICHI, MARUMO, HIROFUTO, OIWA, RUIKO, KATAGIRI, MICHIKO, NAGAI, TOSHIAKI, OMURA, SATOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - classification Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Lethal Dose 50 Mice Mycoplasma - drug effects Quinones - classification Quinones - isolation & purification Quinones - pharmacology Staphylococcus aureus - drug effects Streptomyces - metabolism Trichophyton - drug effects
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Zusammenfassung:	Nanaomycins are new antibiotics produced by the strain OS-3966 which was designated Streptomyces rosa var. notoensis. Nanaomycins A and B were isolated from the culture filtrate by extraction with organic solvent and silica gel chromatography. The physical and chemical properties suggest that nanaomycins A and B are quinone-related compounds having the molecular formulae, C16H14O6 and C16H16O7, respectively. Nanaomycins A and B inhibit mainly mycoplasmas, fungi and Gram-positive bacteria. The acute toxicities (LD50. ip) of nanaomycins A and B in mice are 28.2 and 169 mg/kg, respectively.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.28.860