COMBINED ACTION OF SULBENICILLIN AND GENTAMICIN

Nine laboratory standard strains and 29 clinically isolated strains of Pseudomonas aeruginosa were employed for the studies of combined use of sulbenicillin and gentamicin in vitro. Increased antibacterial activity by the combined use of the two drugs over the activity of either drug alone was obser...

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Veröffentlicht in:	Journal of antibiotics 1974, Vol.27(3), pp.199-205
Hauptverfasser:	NAGATOMO, HIROSHI, KAKIZAKI, MIEKO, TSUCHIYA, KANJI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Synergism Drug Therapy, Combination Gentamicins - administration & dosage Gentamicins - pharmacology Gentamicins - therapeutic use Injections, Subcutaneous Male Mice Penicillin G - administration & dosage Penicillin G - pharmacology Penicillin G - therapeutic use Pseudomonas aeruginosa - drug effects Pseudomonas Infections - drug therapy Pseudomonas Infections - prevention & control Sulfonic Acids - administration & dosage Sulfonic Acids - pharmacology Sulfonic Acids - therapeutic use
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Zusammenfassung:	Nine laboratory standard strains and 29 clinically isolated strains of Pseudomonas aeruginosa were employed for the studies of combined use of sulbenicillin and gentamicin in vitro. Increased antibacterial activity by the combined use of the two drugs over the activity of either drug alone was observed against all the strains tested. Bactericidal activity against P. aeruginosa N 18 was enhanced by combining the two drugs. Synergistic activity of the two drugs was also observed in protective studies against intra-peritoneal infection in mice by several Pseudomonas strains.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.27.199