MECHANISM OF STEROL AND LIPID ANTAGONISM OF A POLYPEPTIDE ANTIBIOTIC, MYCOBACILLIN

MECHANISM OF STEROL AND LIPID ANTAGONISM OF A POLYPEPTIDE ANTIBIOTIC, MYCOBACILLIN

Cholesterol and lecithin can antagonize growth inhibition of Aspergillus niger by mycobacillin only if added at the same time as the antibiotic. Experiments with different derivatives of cholesterol and components of lecithin indicate that the 3-β-hydroxyl group of the former and the oleic acid comp...

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Veröffentlicht in:Journal of antibiotics 1973, Vol.26(6), pp.358-361
Hauptverfasser: HALDAR, AN JAN A, BOSE, S. K.
Format: Artikel
Sprache:eng
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Zusammenfassung:Cholesterol and lecithin can antagonize growth inhibition of Aspergillus niger by mycobacillin only if added at the same time as the antibiotic. Experiments with different derivatives of cholesterol and components of lecithin indicate that the 3-β-hydroxyl group of the former and the oleic acid component of the latter are responsible for antagonistic action.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.26.358