Polymorphisms in ERCC 2 and ERCC 5 and Risk of Prostate Cancer: A Meta-Analysis and Systematic Review

Excision repair cross complementing ( ) group genes play important roles in the nucleotide excision repair (NER) way, which can effectively remove bulky lesions and reduce UV-caused DNA damage by environmental chemicals. Polymorphisms in were thought to be related to prostate cancer (PCa) risk. Howe...

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Veröffentlicht in:Journal of Cancer 2018, Vol.9 (16), p.2786-2794
Hauptverfasser: Liu, Yi, Hu, Yonghui, Zhang, Meng, Jiang, Runze, Liang, Chaozhao
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Sprache:eng
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Zusammenfassung:Excision repair cross complementing ( ) group genes play important roles in the nucleotide excision repair (NER) way, which can effectively remove bulky lesions and reduce UV-caused DNA damage by environmental chemicals. Polymorphisms in were thought to be related to prostate cancer (PCa) risk. However, it has been unclear whether this relationship is consistent. This study aimed to obtain the overall profile regarding the associations between polymorphisms and PCa risk. We identified relevant studies by a systematic search of PubMed, Medline, Embase, Google Scholar databases, Web of Science and Wanfang databases up to April 8, 2018. Odds ratios (ORs) with 95% confidential intervals (95%CIs) were conducted to evaluate the associations. All the statistical analyses were conducted basing on STATA 12.0 software. Finally, a total of 29 previous studies published in 17 publications were included for four polymorphisms in two DNA repair genes (ERCC2 rs1799793, rs238406, rs13181 and rs17655). Overall, we observed no significant connection between these four polymorphisms and PCa risk. However, after stratifying the studies by ethnicity, -rs1799793 polymorphism was associated with an increased risk of PCa in Asian patients and the relationship was subsequently validated with the allelic model, the homozygous model and the recessive model when extracting the data of Asian patients for specific analyses (B vs. A: OR = 1.537, 95%CI: 1.240-1.906, < 0.001; BB vs. AA: OR = 2.089, 95%CI: 1.388-3.145, < 0.001 and BB vs. BA + AA: OR = 1.929, 95%CI: 1.313-2.835, = 0.020). Furthermore, subgroup analyses were also conducted by Hardy-Weinberg Equilibrium (HWE) and source of control, negative results were identified for -rs238406, -rs13181 and -rs17655 polymorphisms ( > 0.050). To sum up, our work demonstrated that -rs1799793 polymorphism is positively associated with PCa risk in Asian population. Further larger-scale studies with subjects of the same ethnicity and biological characteristics are required to verify these findings.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.25356