Experimental Pathological Study on Effects of Iodine Tincture and Trp-P-2 on the Gingiva of the Rat

In this study, the effects of iodine tincture application and Trp-P-2 application on the gingiva of the rat were investigated histologically and immunohistochemistry (PCNA). In the iodine tincture application groups and Trp-P-2 application groups, the gingiva exhibited mild to moderate changes of epithelial dysplasia which were not observed in the gingiva of the control group. These epithelial changes included irregular arrangement and cellular atypia of basal cells, irregular arrangement and proliferation of prickle cells, thickening of the keratinized cell layer and irregular elongation of epithelial projections. The percentages of PCNA-positive cells in the gingiva were statistically significant than that of the control group..