Development of Cerebral Blood Flow Analysis Software for the Diamix^【○!R】One-day Method (modified early method) : Applicability to Cerebral Blood Flow Measurement Using the Microsphere Model

We have developed a new software program that makes it possible to conduct the Diamox one-day method (modified early method)using the microsphere model both quickly and easily, for the measurement of cerebral blood flow using ^ I-IMP. This software program obtains measurements before and after acetazolamide loading (hereafter referred to as Diamox), and allows the use of five imaging methods consisting of combinations of static, dynamic, and continuous and repeated SPECT, to meet the requirements of the singledetector-type camera as well as those of the multi-detector-type gamma camera. In addition, four methods of analysis are available, including continuous arterial blood collection, one-point arterial blood collection (Inoue, Fujioka, et al.), and one-point venous blood collection (Fujioka, et al). Furthermore, the program offers a variety of information such as at-rest SPECT view, response mapping, increase mapping, and subtraction mapping. The correlation between the quantitative value (n=30)obtained by continuous arterial blood collection and each of the above parameters was good: y=0.61X+6.32, r=0.82; y=1.24X+8.29, r=0.95; y=1.13x+5.17, r=0.90 (p