Electrochemical characterization of 1,5-benzodiazepine oximes in organic solvents

Six novel 1,3,4,5-tetrahydro-2H-1,5-benzodiazepine oximes (1–6) were electrochemically characterized on a glassy carbon electrode by the cyclic voltammetry method in different solvents, at different pH values and varying the potential scan rate. The well-defined first anodic peak was observed in the solvents used and acetate buffer solution while the second oxidation peak was dimished or absent for all studied compounds. All compounds were irreversibly oxidized at positive potentials. The electron transfer process for all investigated compounds was controlled by diffusion. Oxidation potentials were dependent on the molecular structures of investigated compounds as well as on the solvent nature.